Shared Flashcard Set

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Chlamydia & Mycoplasma
BBD exam 1 - 3/30/10
35
Medical
Professional
04/10/2010

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Cards

Term
T/F: chlamydia are obligate intracellular bugs.
Definition
TRUE.
Term
can chlamydia make ATP?
Definition
no
Term
do chlamydia have a peptidoglycan layer?
Definition
no
Term
what are the two morphologically distinct forms of chlamydia?
Definition
Elementary Body (EB) & Reticulate Body (RB)
Term
which form is metabolically active?
Definition
Reticulate Body (hence why it's twice as big as the EB)
Term
how does chlamydia avoid destruction in a macrophage?
Definition
prevents fusion of phagosome with lysosome
Term
where does chlamydia first differentiate from an EB to an RB?
Definition
within the endosome/inclusion (the thing in which they entered the host cell).
Term
when do RBs redifferentiate BACK into EBs?
Definition
once they reproduced enough and filled the vacuole they were sitting in. The EBs then exit after lysis of host cell and infect other cells.
Term
name 3 species of Chlamydia:
Definition
trachomatis, psittaci, pneumoniae
Term
which species has a method of transmission from sexual contact?
Definition
C. trachomatis
Term
which species has a method of transmission from bird droppings?
Definition
C. psittaci
Term
which species has a method of transmission from person to person?
Definition
C. pneumoniae
Term
what is the most common cause of STIs?
Definition
C. trachomatis
Term
what genital infections might C. trachomatis cause in women?
Definition
pelvic inflammatory disease (although nearly 80% of women are asymptomatic)
Term
what is Reiter's Syndrome?
Definition
Autoimmune disease caused by cross-reactivity of antibodies to C. trachomatis
Term
what major infection from C. trachomatis occurs in newborns?
Definition
inclusion conjunctivitis
Term
T/F: Endemic trachoma (conjunctivitis) have the same serotypes as those strains that cause genital infections
Definition
FALSE
Term
how is endemic trachoma (conjunctivitis) spread?
Definition
flies, fingers, fomites
Term
what effects may result on the eye from conjunctivitis (not the newborn type)?
Definition
scarring and loss of vision
Term
is Lymphogranuloma Venerum (LGV) sexually transmitted?
Definition
YES
Term
which lymph nodes are involved in LGV?
Definition
inguinal lymph nodes
Term
what is a zoonotic infection?
Definition
passed from animals to humans
Term
what does C. psittaci induce?
Definition
pneumonia
Term
which bug can be the cause of walking pneumonia?
Definition
C. pneumoniae
Term
what is the "gold standard" for diagnosing Chlamydia infections?
Definition
culture them in McCoy cells (host epithelial cells)
Term
are chlamydia free-living?
Definition
no, they are obligate intracellular bugs
Term
what are the smallest, free-living bacteria?
Definition
mycoplasma
Term
Mycoplasma pneumoniae is a pathogen in which portion of the respiratory tract (upper or lower)?
Definition
lower
Term
which system is infected by Mycoplasma genitalium and Ureaplasma?
Definition
Genitourinary
Term
T/F: Mycoplasma form pleomorphic filaments
Definition
TRUE
Term
do mycoplasma have a peptidoglycan layer?
Definition
NO
Term
do mycoplasma contain cholesterol in their membrane?
Definition
YES, they are the only bugs that do!
Term
where does Mycoplasma attach to host?
Definition
on the cilia in trachea (bronchi and bronchioles)
Term
what distinguishes Ureaplasma urealyticum from Mycoplasma?
Definition
it produces a lot of urease
Term
are mycoplasma intracellular or extracellular?
Definition
ONLY extracellular
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