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Chemo Drugs
Vrana Chemo
22
Medical
Graduate
05/12/2011

Additional Medical Flashcards

 


 

Cards

Term
Antimetabolite
Definition
interfere with nucleic acid synthesis
Term
Alylating agent
Definition
covalently binds to DNA
Term
antitumor antibiotic
Definition
distrupts DNA structure and funtion
Term
antimitotic agents
Definition
block topoisomerase or microtubule function
Term
hormonal agents
Definition
affect signaling through steroid receptors
Term
Signaling inhibitors
Definition
block signaling pathways
Term
Hematopoeitic Growth factos
Definition
promote recovery of blood cells after chemo
Term
Mechanism of alkylating agents
Definition
damage DNA by breaks, crosslinks, or mutations (mustards, nitrosoureas, platinum, methylating agents)
Term
Classes of antimetabolites
Definition
Folate, pyrimidine, and purine analogs, and ribonucleotide reductase (hydroxyurea)
Term
Mechanism of folate analogs
Definition
competitive inhibitor of dihydrofolate reductase (DHFR)
Term
Mechanism of pyrimidine analogs
Definition
suicide inhibitor, kills thymidylate synthase prevents methylation
Term
Classes of antimitotic (natural) agents
Definition
Microtubule inhibitors and topoisomerase inhibitors
Term
mechanism of microtubule inhibitors
Definition
disrupting MT causes apoptosis; can prevent dissociation or inhibit by binding
Term
mechanism of topoisomerase inhibitors
Definition
prevent unwinding of DNA or cause double strand breaks
Term
mechanism of antibiotics
Definition
intercalate b/w bases, cause uncoiling, oxygen free radicals, disrupt signal transduction
Term
mechanism of L-Asparaginase
Definition
uses up low levels of asparagines in cancer cells - selective inhibiton of cancer cells
Term
classes of hormonal agents
Definition
glucocorticoids, progestin, antiestrogens, aromatase inhibitors antiandrogens, LHRH agonists
Term
Mechanism of glucocorticoids
Definition
prevent macrophage presentation, stop proliferation and differentiation of leukocytes
Term
classes of immunomodulatory agents
Definition
cytokines, signaling inhibitors, protein kinase inhibitors, angiogenesis inhibitors, proteosome inhibitors
Term
Mechanism of cytokines
Definition
interferon and interleukins stimulate NK cells to fight, interferon alpha small proteins interfere with protein synthesis
Term
mechanism of signaling inhibitors
Definition
stop surface receptor or other part of signaling pathway from sending signals
Term
Use of Imatinib (Gleevac)
Definition
selective BCR-ABL inhibitor in CML
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