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Chemistry Internship Study Questions Section 2
B12/Folate, Tumor Markers, Lactate, & Amniotic Fluid Testing
39
Chemistry
Undergraduate 4
11/10/2015

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Term
What are the specimen handling requirements for plasma folate analysis?
Definition
Protect from light. Heparin tubes
Term
What is the required collection tube for RBC Folate?
Definition
EDTA
Term
Are there any pretreatment requirements before running a RBC Folate?
Definition
Add lysing reagent to make a hemolysate
Term
What benefits are there to quantitating a RBC Folate rather than a serum/plasma folate?
Definition
Serum levels reflect a day-to-date Folate consumption;
RBC Folate reflects a chronic condition
Term
Describe the RBC Morphology associated with B12/Folate Deficiencies
Definition
Macrocytic / Megaloblastic
Term
What is the Disease risk associated with Folate Deficiency in Pregnant Women?
Definition
Neural Tube Defects
Term
Is there a test which can help determine the risk of Folate Deficiency in Pregnant Women?
Definition
AFP on Maternal Serum & Amniotic fluid
Term
Match the Tumor Marker with the Primary Tumor Source:

PSA
Definition
Prostate
Term
Match the Tumor Marker with the Primary Tumor Source:

Cortisol
Definition
Adrenal
Term
Match the Tumor Marker with the Primary Tumor Source:

CA 125
Definition
Ovarian
Term
Match the Tumor Marker with the Primary Tumor Source:

HCG
Definition
Choriocarcinoma, Testicular
Term
Match the Tumor Marker with the Primary Tumor Source:

AFP
Definition
Hepatocellular / Choriocarcinoma, Testicular
Term
Match the Tumor Marker with the Primary Tumor Source:

CEA
Definition
GI, Colon, Lung
Term
Match the Tumor Marker with the Primary Tumor Source:

HE4
Definition
Breast
Term
Match the Tumor Marker with the Primary Tumor Source:

CA 15-3
Definition
Breast
Term
Match the Tumor Marker with the Primary Tumor Source:

CA 19-9
Definition
Pancreatic & Colorectal
Term
Match the Primary Tumor Source with the Tumor Marker that tests for that area:

Prostate
Definition
PSA
Term
Match the Primary Tumor Source with the Tumor Marker that tests for that area:

Adrenal
Definition
Cortisol
Term
Match the Primary Tumor Source with the Tumor Marker that tests for that area:

Ovarian
Definition
CA 125
Term
Match the Primary Tumor Source with the Tumor Marker that tests for that area:

Choriocarcinoma, Testicular
Definition
HCG
Term
Match the Primary Tumor Source with the Tumor Marker that tests for that area:

Hepatocellular / Choriocarcinoma, Testicular
Definition
AFP
Term
Match the Primary Tumor Source with the Tumor Marker that tests for that area:

GI, Colon, Lung
Definition
CEA
Term
Match the Primary Tumor Source with the Tumor Marker that tests for that area:

Breast
Definition
HE4 & CA 15-3
Term
Match the Primary Tumor Source with the Tumor Marker that tests for that area:

Pancreatic & Colorectal
Definition
CA 19-9
Term
What TISSUE RECEPTOR tests can be done to help determine the BEST COURSE OF TREATMENT for a woman with BREAST CANCER?
Definition
Estrogen & Progesterone Receptor
Term
What abnormal conditions cause an accumulation of Lactic acid in the blood?
Definition
Tissue hypoxia from shock, Heart disease or Heart attack, Sepsis, Lung Disease, & Severe Crush Injuries
Term
Are there any "NORMAL" Conditions that can cause INCREASED LACTATE?
Definition
Exercise
Term
Describe the proper collection tube and handling requirements when testing for Lactate
Definition
Gray Top, Put on Ice, Deliver ASAP
Term
What is the "PREDICTIVE" Function of a RISING LACTATE level?
Definition
Increased Levels = Increased Mortality
Term
What is the most common test done to assess Fetal Lung Maturity?
Definition
Albumin Surfactant Test;
L/S Ratio;
PG
Term
What surfactant serves as a final indicator of Fetal Lung Maturity at the End of Gestation?
Definition
PG
Term
What Condition will result in a Newborn who does NOT have sufficient surfactant?
Definition
Respiratory Distress Syndrome (RDS)
Term
What is the cause of Hemolytic Disease of the Newborn (HDN)?
Definition
Incompatible blood type between mother and baby (usually Rh)
Term
What test can be performed on Amniotic fluid to aid in diagnosing and monitoring HDN?
Definition
bilirubin (OD450)
Term
What is the GREATEST Risk to an infant born with HDN?
Definition
Anemia & Kericterus
Term
What type of graph can be used to assess the severity of HDN?
Definition
Liley Graph;
Zones indicate severity of anemia
Term
Neural Tube Defects (NTD) are associated with Elevated levels of What substance in Maternal Serum and Amniotic Fluid?
Definition
Alpha FetoProtein (AFP)
Term
What dietary deficiency has been associated with Neural Tube Defects (NTD)?
Definition
Folic Acid/Folate Deficiencies
Term
What cervical swab test serves as an Indicator of Impending Delivery?
Definition
Fetal Fibronectin
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