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Chapter 4: Tissues
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23
Physiology
Undergraduate 1
04/12/2013

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Term
About how many different cells are there in the human body?
Definition
~ 200
Term
What are tissues?
Definition
Collections of cells and their products working together to perform certain specialized functions.
Term
What is histology?
Definition
The study of tissues.
Term
What are the two broad categories of epithelial tissue?
Definition
Epithelia and glands.
Term
What are the two categories of glands and their general characteristics?
Definition
Exocrine - Tissues that secrete onto external surfaces/internal passages (ducts) that connect to the exterior. Examples: sweat and salivary glands.
Endocrine - tissues that secrete hormones or their precursors into interstitial fluid, usually for distribution to blood stream.
Term
What are the four essential functions of epithelial tissues?
Definition
1. Physical protection
2. Control of permeability
3. Provision of sensation
4. Production of specialized secretions
Term
How does the epithelium provide protection from physical damage?
Definition
It lines all exposed surfaces of the body and body cavities and protects against abrasion, dehydration, and damage from chemical and biological agents.
Term
How does the epithelium control permeability?
Definition
All substances that enter the body must do so through the epithelium. These tissues have selectively permeable membranes which can be altered and controlled to increase/decrease the permeability of a given substance.
Term
How does the epithelium provide sensation?
Definition
Signals from the special senses originate in modified epithelial tissue that sense changes in pressure or heat and produce a signal that is carried by the nerves to the spinal cord and brain.
Term
Describe some of the common characteristics of epithelial tissue:
Definition
- Base and apical surfaces. The base surface anchors the cell. The apical surface faces the exterior space, or is the secretory surface.
- Microvilli or cilia are common on the apical surface.
- Nucleus, Mitochondria, ER, and Golgi
Term
What is a lumen?
Definition
The interior diameter of a passageway.
Term
What are the basolateral surfaces?
Definition
The non-apical surfaces - sides and base that give support and anchorage to the cell.
Term
What does polarity refer to in regards to cells?
Definition
Having a structural difference between exposed and attached sides.
Term
What are the three shapes of epithelial cells?
Definition
Squamous - flat
Cuboidal - squared
Columnar - tall...like columns
Term
What is a simple epithelium layer?
Definition
Cells in a single layer.
Term
What is meant by stratified epithelium?
Definition
Multiple layers of epithelium.
Term
What are occluding junctions and how do they work?
Definition
These seal the spaces between cells, preventing leakage of fluids and molecules around the sides of the cells. They involve the lipid portions of the cell membrane being tightly bound by interlocking proteins.
Term
What is an adhesion belt, and how does it work?
Definition
These provide extra rigidity and support to epithelial cells. A strong belt of fibers anchors the terminal web to the cell wall and to neighboring cells.
Term
What are gap junctions, and how do they work?
Definition
These are groups of connexons that facilitate the movement of small molecules (especially ions) from one cell to another. They are also important in cardiac muscle.
Term
How do connexons work?
Definition
These protein channels are imbedded in the plasma membranes of adjacent cells. The lumens of the channels line up, permitting unhindered movement of ions back and forth from one cell to another.
Term
What are desmosomes, and how do they work?
Definition
These secure neighboring cells together. They included Cell Adhesion Molecules.
Term
What are Cell Adhesion Molecules (CAMs)?
Definition
These transmembrane proteins have a head that sticks out into the extracellular space. The heads from the opposing desmosome on the neighboring head bind together, locking fast adjoining cells.
Term
What is intercellular cement?
Definition
A thin layer of proteoglycans that contain polysaccharide derivatives. These glue neighboring plasma membranes together.
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