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Breast
Anatomy & Pathalogy
89
Pathology
Professional
08/10/2011

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Term
What type of changes can occur in the breast due to hormonal changes in the body?
Definition
Pubertal
Fibrocystic
Gynecomastia
Term
Fibrocystic changes in the breast can create what features?
Definition
Fibrosis
Cystic change
Sclerosing adenosis
Term
What is Gynecomastia?
Definition
Female like enlargement of male breast
Term
What are risk factors of carcinoma in the breast?
Definition
Female are greater
Family history
White-African-east asian
Premalignant breast changes
Cause other cancers
Term
What type of premalignant changes occur due to carcinoma of the breast?
Definition
Papillomatosis
Atypical hyperplasia
Term
what other cancers can result from carcinoma of the breast?
Definition
Ovary
Uterus
Breast
Term
What age should women start getting breast exams?
Definition
45
Term
Most tumors of breast cancer metastases to where?
Definition
Axillary lymphnodes
Internal mammary lymph nodes
Term
The most common metasteses site from breast cancer is?
Definition
Axillary lymph nodes
Term
In addition to lymph node metasteses, tumors may tend to spread to where?
Definition
Brain
Lung
Liver
Adreenal
Bone
Term
What quadrant of the breast are most tumors found?
Definition
Upper lateral quadrant (45%)
Term
What quadrants are the breast divided into?
Definition
UO
UI
LO
LI
Term
The nipple is what percentage to get cancer?
Definition
25%
Term
What are the clinical presentation of breast carcinoma?
Definition
Breast mass discovered by palpatation
Tumor discovered by mammagraphy
Painful (mastodynia) breast
Nipple retraction, skin retraction, discharge
Metastases
Term
Lesions of the male breast are?
Definition
Gynecomastia
carcinoma
100x less common than women
Identical to carcinoma of female breast
Term
What is the most common form of breast cancer for men?
Definition
Invasive ductal carcinoma
Term
What frequency probes do we use for breast?
Definition
10-15 MHz
Term
what is another name for accessory nipple?
Definition
supernumory nipple
Term
what is the breast tissue called that ends in the axilla?
Definition
axillary of spenca
Term
what are the 3 layers of breast tissue between the skin and the chest wall?
Definition
subcutaneous layer
mammary layer
retromammary layer
Term
_______________ & _____________ tissue are thin?
Definition
subcutaneous
retromammary
Term
fat is described how sonographically?
Definition
hypoechoic
Term
volume and echogenicity of the breast tissue depends on pt's?
Definition
general inherited breast tissue pattern
functional state of the breast
Term
Are lypoma's are echogenic or hypoechoic?
Definition
hypoechoic
Term
what are cooper's ligaments?
Definition
echogenic tissue that holds the breast in place
Term
Mammary layer?
Definition
includes the functional portion of the breast as well as the surrounding tissue
emanate from the nipple in pattern like spokes of a wheel
Term
the mammary layer contain how many lobes?
Definition
15-20
Term
Most tumors originate where?
Definition
UOQ
Term
The mammary layer contains hundred's of _________ in each breast?
Definition
acini
Term
How are the terminal ductal-lobular unit formed?
Definition
the terminal ducts and the acini form small lobular units called TDLU
Term
what is TDLU?
Definition
is the site of origin of nearly all pathologic processes that occur within the breast
Term
the space between the lobes is _______?
Definition
stroma
Term
what is the functional unit of the breast?
Definition
terminal ductal-lobular unit
Term
stroma are located where?
Definition
between and within the lobes
Term
stroma consist of ?
Definition
dense connnective tissue, loose connective tissue and fat
Term
stroma are also called?
Definition
cooper's ligaments
Term
what muscles are posterior to the retromammary layer?
Definition
pectoralis major
Term
what muscle is located superolateral and posterior to the pectoralis major?
Definition
pectoralis
Term
Muscles are described how sonographically?
Definition
hypoechoic interface between the retromammary layer and ribs
striated
Term
appearance and pattern of breast tissue vary?
Definition
from woman to woman
depending on stage in life
Term
in young females the breast appear?
Definition
fibrous
reflects a dense echogenis pattern
Term
in the pregnant or lactating female the breast appears?
Definition
glandular portions of the breast proliferate in both density and volume
Term
as the woman ages the breast appears?
Definition
replaced with fat
more hypoechoic
Term
where does the lymphatic drainage flow to?
Definition
to the axillary lymph nodes
Term
what is it called when a male has enlarged breast tissue?
Definition
gynocomastia
Term
what is it called when you have xxy (both male and female parts)?
Definition
Klinefelter's syndrome
Term
What percentage of males get breast cancer?
Definition
1%
Term
what males are at a higher risk for breast cancer?
Definition
klinefelter's syndrome
male to female transexual
hx of chest wall irradiation
hx of orchitis or testicular tumor
liver disease
genetic predisposition
Term
When does breast development start?
Definition
before the onset of menstration and continues for the first 2 yrs of menstrual cycles
Term
what are the 3 catagories for breast imaging?
Definition
breast cancer screening
diagnostic imaging
diagnostic and interventional breast procedures
Term
breast cancer screening involves?
Definition
monthly self examination by pt
regular clinical breast by a physician
yearly screening mammography over 40
Term
what are the main imaging tools for breast evaluation?
Definition
mammography
brest us
mri
Term
The __________________________ has established guidelines for standardized description and reporting of breast lesions identified with mammography?
Definition
American College of Radiology
Term
what are BI-RADS?
Definition
Breast imaging reporting and data system
Term
Mammography usually starts at what age?
Definition
40
Term
Pertinent pt information should include when doing an us?
Definition
pt age
risk factors for breast cancer
location of lumps
other symptoms
hx of trauma to breast
Term
what is the most often reason for breast us?
Definition
palpable lump
Term
information to be provided from physician when ordering an us?
Definition
lump size
location with in the breast
onset and duration of the breast prob
LMP
Term
when inspecting the breast for us what are you looking for?
Definition
nipple retraction
skin thickening (edema, scar,peau d ornage)
signs of inflammation
contustion
Term
cyst are usually?
Definition
round, oval
smooth, soft
easily moves
Term
fibroadenomas are usually?
Definition
similar in shape to cyst
often quite firm and rubbery
Term
breast cancers are usually?
Definition
painless
lobular or irregular shape
uneven in surface contour
poorly movable
Term
US is the primary tool in breast imaging for women under the age of ?
Definition
30
Term
what annotaion do you use for breast?
Definition
clock face method
zone method
depth of lesion
radial & antiradial
Term
what is the zone method?
Definition
3 circles around nipple
labeled 1,2,3
Term
what is depth of lesion
Definition
labeled
a
b
c
Term
what are the procedurs for tissue diagnosis?
Definition
biopsy
FNA
excision
Term
what is femitus?
Definition
palpable tremor or vibration
Term
It is malignant when what is larger than what?
Definition
more taller than wider
AP greater than width
Term
what is FCC?
Definition
fibrocystic condition
Term
what are clinical signs/ sympt of FCC?
Definition
lumps and pain that fluctuate with every monthly cycle
Term
what is the most common benign breast tumor?
Definition
fibroadenoma
Term
fibroadenoma is characterized?
Definition
in young women
stimulated by estrogen
firm, rubbery, mobile mass
grow slowly
hyperechoic
Term
lipoma
Definition
fatty tissue
soft mass with poor margins
tough to see in fatty tissue
Term
acute mastitis
Definition
caused by infection, trauma, obstruction of duct
occurs during lactation
enlarged, red, tender
treat with antibiotics
Term
chronic mastitis
Definition
inflammation of glandular tissue
difficult to see on us
clinically nipple discharge and retraction
Term
abcess
Definition
single or multiple
acute- poor defined border
mature- well defined border
pain, swelling, reddening of skin
febrile
Term
malignancies take how long to develope?
Definition
2 yrs
Term
malignancies are most likely located?
Definition
UOQ
Term
2 types of malignancies?
Definition
sarcoma
carcinoma
Term
sarcoma?
Definition
from connective tissue
rapid growth
invade fibrous tissue
Term
carcinoma?
Definition
arise from epithelium in the ducts and glands
have tentacles
Term
what makes up 80% of breast cancer?
Definition
IDC
invasive ductal carcinoma
Term
ductal carcinoma in situ- DCIS
Definition
intraductal carcinoma
no spread outside ducts
100% cure rate
Term
paget's disease
Definition
grows in the direction of nipple
rashlike appearance
any deformity of nipple suggest pagets
Term
scirrhous carcinoma
Definition
most common
intraductal tumor with extensive fibrous growth
Term
lobular carcinoma in situ- LCIS
Definition
not cancer due to low malignancy
lobular neoplasia
precancerous
Term
invasive lobular carcinoma- O:C
Definition
begins in the lobule
extends into the fatty tissue
Term
Sentinal node injection?
Definition
injected with dye
taken up by lymphatic system to the 1st sentinel node
sample taken from node to be analyzed
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