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Cell Molec terms
WWU biol323
33
Biology
Undergraduate 4
12/11/2012

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Term
alpha tubulin
Definition
one globular subunit of microtubules
binds GTP but it cannot be hydrolyzed
makes up the - end of the microtubule filament
Term
beta tubulin
Definition
one globular subunit of microtubules
Binds GTP and can be hydrolyzed
makes up the +end of the microtubule filament
Term
T form
Definition
Triphosphate bound
Term
D form
Definition
Diphosphate bound
Term
Ketatins
Definition
part of the IF family, very diverse, related to desmosomes which are cell to cell contact.
Term
y tubulin
Definition
makes up the y-TuRC
Term
y-TuRC
Definition
Tubulin ring complex, it binds to the - end where the microtubule is connected to the MTOC. It initiates nucleation.
Term
ARPs
Definition
Actin Relate Proteins, nucleate actin filaments from the - end. Nucleation normally occurs near the plasma membrane. It nucleates best when attached to another filament so a meshwork begins to form.
Term
WaSP
Definition
when WASp binds to Cdc42 it changes conformation and allowsARP to bind and nucleation to begin.
Term
Formins
Definition
assemble unbranched actin filaments. Associated with the + end.
Term
Thymosin
Definition
binds actin monomers and prevents assembly, they can't hydrolyze their ATP
Term
Proflin
Definition
binds actin monomers, it binds to the face that would normally bind the - end. this makes the monomer more likely to bind the + end and this makes assembly go faster.
Term
Stathmin
Definition
binds heterodimers- prevents their addition to the + end.
Term
Gelsolin
Definition
severs actin filaments, its activated at high Ca levels. it doesn't require extra energy input
Term
Katanin
Definition
severs microtubule filaments, 13 bonds must be broken. Requires ATP
Term
MAPs
Definition
Microtubule associated proteins, bind along the side of the microtubule, stabilize against disassembly, abundant in neurons.
Term
MAP2
Definition
produces evenly spaced MT bundles
Term
Tau
Definition
Forms MT bundles more closely packed
Term
kinesin 13
Definition
Catastrophe factor, increases frequency of catastrophe.
Term
Coflin
Definition
binds to actin subunits and filaments- twising the helix tighter and causing instability.
Term
tropomysin
Definition
elongated protein that coats the actin filament and stabilizes it.
Term
Cap Z
Definition
Binds to the + end of actin where the filaments grow
Term
topomodulin
Definition
binds to the - end where the actin filaments desassemble
Term
sarcomere
Definition
from Z disc to Z disc, muscle fibers. built from CapZ and actin and myosin.
Term
nebulin
Definition
dictates the length of the actin filament
Term
titin
Definition
acts like a spring that positions the thick actin filament
Term
troponin
Definition
binds actin and tropomyosin
Term
MLCK
Definition
myosin light chain kinase- the myosin head must be activated in order for ATP to bind. it activates myosin.
Term
Kinesin
Definition
moves toward the + end, ATP driven, one head group is always attached.
Term
Dynein
Definition
moves toward the - end, moves on MTs.
Term
Dynactin
Definition
binds to Dynein to bind the cargo
Term
Ash1mRNA
Definition
localized to the buddin gyeast cell so that it ends up in the daughter cell.
Term
CDC42
Definition
Rho family, GTPase, activates WASp and ARP complex to initiate actin polymerization, Also can activate Rho and formin.
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