Shared Flashcard Set

Details

CD Ags
N/A
28
Medical
Professional
08/28/2009

Additional Medical Flashcards

 


 

Cards

Term
CD1
Definition

DCs, Langerhas, some thymocytes, monocytes, activated Ts, epithelial cells

 

  • Display of nonpeptide and glycolipid Ag for γδ and NKT cell responses
Term
CD3
Definition

Thymocytes, Ts, NKTs

 

  • Essential role in TCR signal transduction and in cell surface expression of the TCR
Term
CD4
Definition

MHC II-restricted cells, some thymocytes, monocytes/mΦ, granulocytes

 

  • co-receptor for MHC II-restricted T cell activation
  • thymic differentiation marker for Ts
  • receptor for HIV
Term
CD5
Definition

Mature Ts, early thymocytes, B1as

 

  • Marker of a B1 cells, which do not undergo somatic hypermutation,produce mainly IgM, and do not require T cell help
Term
CD8
Definition

MHC I-restricted Ts, some thymocytes, subset of DCs

 

  • co-receptor for MHC-I restricted Ts
Term
CD10
Definition

B cell precursors, T cell precursors, bm stromal cells, neutrophils, monocytes, keratinocytes

 

  • membrane-bound metallopeptidase responsible for cleaving a variety of inflammatory and vasoactive peptides
Term
CD14
Definition

monocytes, mΦ, granulocytes, Bs, DCs, hepatocytes

 

  • receptor for LPS, activating monocytes/ neutrophils to release cytokines (TNF) and up-reg adhesion molecules when LPS is bound
  • binds peptidoglycan on gram+ bacteria, Hp60, ceraminds, modified lipoproteins, and anionic phospholipids
  • soluble form reported to act as an acute phase protein and may regulate T cell activation and act as B cell mitogen
Term
CD16
Definition

NKs, mΦ, mast cells, neutrophils, myeloid precursors, and the majority of early CD4+-CD8+- TCR fetal thymocytes

 

  • subunit of low-affinity FcγR involved in phagocytosis of Ab-complexed Ag and in ADCC
Term
CD19
Definition

FDCs, Bs (until plasma cells)

 

  • part of B cell coreceptor w/ CD21 + CD81
  • critical signal transduction molecule that regulates B cell development, activation, and differentiation
Term
CD20
Definition

Bs

 

  • ligation acivates tyrosine kinase-dependent pathways and may have a role in B cell proliferation and differentiation
  • regulates B cell activation and proliferation via regulation of transmembrane Ca2+ channel subunit and cell-cycle progression
Term
CD21
Definition

Bs, FDCs, subset of immature thymocytes

 

  • receptor for C3d and iC3d (CR2)
  • EBV receptor
  • with CD19 and CD81, part of B cell coreceptor, a large signal transduction complex
Term
CD28
Definition

Mature CD3+ thymocytes, most peripheral Ts, plasma cells

 

  • Co-stimulation of T cell proliferation and cytokine production, upon binding CD80 or CD86
Term
CD34
Definition

early lymphohematopoietic stem and progenitor cells, small-vessel endothelial clels, embryonic fibroblasts, some cells in fetal + adult nervous tissue

 

  • cell-cell adhesion molecule
  • also participates in inhibition of hematopoietic differentiation
Term
CD35
Definition

erythrocytes, neutrophils, monocytes, eosinophils, Bs, and 10 - 15% of thymocytes

 

  • CR1 - receptor for C4b/C3b - coated particales, mediating their adherence and phagocytosis
  • facilitation of C3b and C4b cleavage, thus limiting complement activation
Term
CD40
Definition

all mature B cell lineages except plasma cells, mΦ, FDCs, activated monocytes, endothelial cells, fibroblasts, DCs, keratinocytes, CD34+ hematopoietic cell progenitors

 

  • binds to CD154 (CD40L)
  • roles in B cell growth, differentiation, and isotype switching
  • apoptosis rescue signal for germinal center Bs
  • stimulation of cytokine production in mΦ and DCs
  • up-red of adhesion molecules in DCs
  • plays a critical role in the regulation of cell-mediated immunity as well as Ab-mediated immunity
Term
CD45
Definition

all hematopoietic cells except RBCs

 

  • tyrosine phosphatase that may remove Ps from signal transduction molecules involved  in T cell signalling, thus activating them
  • regulates a variety of cellular processes, including cell growth, differntiation, mitotic cycle, and oncotic transformation
  • essential role in T and B cell Ag-receptor mediated activation
  • possible role in receptor-mediated activation in other leukocytes
Term
CD46
Definition

PBLs

 

  • MCP - binds the complement components C3b and C4b, allowing degradation by Factor I
Term
CD80
Definition

Activated Bs and Ts, mΦ, low levels on resting peripheral blood monocytes and Dcs

 

  • binds CD28 and CD152
  • co-stimulator of T cell activation with CD86 when bound to CD28
  • inhibits T cell activation when bound with CD152
Term
CD86
Definition

DCs, memory Bs, germinal center Bs, monocytes

 

  • B70 - major T cell costimulatory molecule, interacting with CD 28 (stimulatory) and CD152 (inhibitory)
Term
CD95
Definition

activated Ts and Bs, monocytes, fibroblasts, neutrophils

 

  • Fas - mediation of apoptosis-inducing signals
Term
CD152
Definition

Activated Ts, perhaps some activated Bs

 

  • negative regulator of T cell activation
Term
CD154
Definition

Activated CD4+ Ts, small subset of CD8+ Ts and γδ Ts, activated basophils, platelets, monocytes, mast cells

 

  • CD40L, inducer of B cell proliferation and activation, Ab class switching and germinal center formation
  • costimulatory molecule and a regulator of TH1 generation and fxn
  • role in negative selection and peripheral tolerance
Term
CD 11b/18
Definition

granulocytes, monocytes, NKs, subset of Ts and Bs, myeloid DCs

 

  • CR3 - mediates phagocytosis of particles coated with iC3b or IgG
Term
CD11c/18
Definition

monocytes, mΦ, NKs, granulocytes, subset of Ts and Bs, DCs

 

  • CR4
  • similar to CR3
Term
CD59
Definition

most hematopoietic and nonhematopoietic cell types

 

  • binds to C8 and C9, may bind CD2
  • inhibitor of MAC assembly
Term
CD32
Definition

Bs, monocytes, mΦ, Langerhans, neutrophils, platelets

  • FcγRll receptor for Fc portion of Ag-Ab-complexed IgG
  • Major inhibitory role preventing the development of autoimmune disease
  • Plays a major role in immune complex-induced tissue damage
Term
CD79
Definition

 

  • Igα and Igβ, required for signalling through BCR
  • analogous to CD3
Term
CD43
Definition

All leukocytes except most resting BS

 

  • Plays an important role in cell signal trandsuction and mediation of the cytoskeleton
  • Mutated in Wiskott-Aldrich syndrome
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