Shared Flashcard Set

Details

Caswell 1
Tissue Repair
22
Veterinary Medicine
Not Applicable
03/15/2017

Additional Veterinary Medicine Flashcards

 


 

Cards

Term
First stage of stromal tissue healing?
Definition
fibrous/serous effusion, fibrin forms a scaffold for cell mgiration
Term
How far along in wound healing would you expect to see fibroblasts & blood vessels invading the wound?
Definition
2-3 days
Term
What key feature of tissue healing occurs around day 6?
Definition
collagen secretion by fibroblasts (formation of granulation tissue)
Term
What chemical mediators secreted by macrophages and platelets promote angiogenesis?
Definition
VEGF
bFGF
Term
What chemical mediators secreted by macrophages & platelets promote fibroblast infiltration & collagen secretion?
Definition
TGF-beta
PDGF
Term
The proliferative phase of wound healing typically ends ___ days post-injury
Definition
15
Term
What is involve with wound remodelling & contraction?
Definition
collagen maturation (Type III -> Type I)

cross-linking of collagen bundles (increases strength)

wound contraction
Term
What are the requirements for epithelial tissue to be able to repair?
Definition
-mitotically active epithelium
-CT framework intact
-vascular supply
Term
Which chemical mediator tends to cause less scarring TGF-beta or PDGF?
Definition
PDGF
Term
The first component of the ECM secreted by fibroblasts after arrival to an injury site
Definition
fibronectin
Term
What is the role of proteases during would healing?
Definition
they remove the initin fibrin scaffold
Term
Wound contraction is mediated by...
Definition
myofibroblasts
Term
Sutured wounds heal by ____ intention
Definition
first
Term
What are osteoprogenitor cells?
Definition
pluripotent cells that migrate from the periosteum and endosteum, to differentited into fibroblasts/osteoblasts/chondroblasts depending on location
Term
Osteoprogenitor cells in well-vascularized regions (e.g. medullary cavity) will form.....
Definition
osteoid (will mineralize to form bone)
Term
Osteoprogenitor cells in poorly-vascularized regions will form.....
Definition
chondrocytes
Term
In bone, the equivalent to granulation tissue is called...
Definition
a callus
Term
Site of bone repair
Definition
internal callus
Term
What effect do corticosteroids have on wound healing?
Definition
delays healing bc reduces macrophage function, impairs fibroblast production of collagen
Term
What is contracture?
Definition
wound countraction in areas where skin is attached to underlying tissues
Term
What is stricture?
Definition
Constrition of the lumen of a tubular organ, resulting from contraction during tissue repair
Term
What is an adhesion?
Definition
when fibrous tissue forms between two organs
Supporting users have an ad free experience!