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Case1-Immunology
Autoimmunity
29
Accounting
Pre-School
02/25/2012

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Cards

Term
Immunogenic
Definition
Activation leading to proliferation
Term
Tolerogenic
Definition
Killed or innactivated
Term
Where does central tolerance occur
Definition
Bone Marrow and Thymus
Term
Negative selection
Definition
immature lympho. when presented w self antigens are instructed to apoptosize if they react
Term
CD 4+
Definition
Class II MCH
Term
CD *+
Definition
MHC Class I
Term
Periferial Tolerance
Definition
Mature T cells preseneted with a self antigen will be innactivated
Term
Anergy
Definition
Innactivation of mature T cells
Term
AIRE
Definition
AutoImmune REgulator- protein in thymus that presents perephrial protein antigens
Term
Loss of AIRE
Definition
AI Polyendocrine Syndrome
Term
B7 Proteins
Definition
Costimulators of immune response of T cells
Term
Inhibitory Receptors
Definition
CD28
Term
Cytotoxic T Lymphocye antigen 4 (CTLA4)
Definition
shuts off T cell response, but can also recognize B7 and lead to activation
Term
Regulatory T Cells
Definition
Block the formation of lymphocyte proliferation if they are active against Self.
Term
Foxp3
Definition
Transcription factor used by CD25, Il-2 alpha receptor. TGF-B uses Foxp3 to help block stimulation
Term
3 Cell Death Mechanisms
Definition
Excessive proapoptotic proteins leads to mitochondrial leak of proteins and caspases

Normal antiapoptotic protein produced but no costimulation leads to death

Death receptor: FAS protein(CD95:memory cells) and FAS ligand (FASL: TCELLS) leads to apoptosis when combined
Term
Autoimmine Lymphoproliforative Syndrome
Definition
Mutation in apoptosis mechanisms
Term
B Cells adaptibility to self antigens
Definition
Receptor change or death
Term
Receptor editing
Definition
New IG chain producted and makes new receptor
Term
SLE
Definition
defective T and B cell tolerance
Term
B Cell + Antigen with no T cell help
Definition
Anergy
Term
HLA DR3/4 issue
Definition
T1DM
Term
HLA DR4
Definition
Pemphigus Vulgaris
Term
HLA Dr4
Definition
RA
Term
HLA B27
Definition
Anklosing spondylitis
Term
AIRE mutation
Definition
autoimmune polyendocrine syndrome- defective T cell elimination
Term
FAS/FASL
Definition
ALPS- AI Lymphocyte proliferation syndrome
Term
Foxp3 mutation
Definition
X Linked polyneuropathy
Term
NOD-2 Mutant
Definition
Crohn's disease
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