Shared Flashcard Set

Details

Cardiovascular Drugs
Pharm
12
Medical
Graduate
11/17/2012

Additional Medical Flashcards

 


 

Cards

Term
Thrombolytics- Alteplase
Definition
Catalyzes formation of plasmin from plasminogen bound to fibrin

Breaks down clots
Term
Hemostatics- antihemophiliac factor recominant
Definition
Functions as cofactor 9a which converts X to Xa and coagulation cascade

May cause factor 8 inhibitory disorder (hemophilia)
Term
Treatments for cardiac arrhythmias
Definition
Class 1B- lidocaine- inhibits Na channel-->decrease sodium current-->decrease pacemaker activity; AE- neurological

Class 2- beta blockers- propanalol- inhibits cardiac b1/2 adrenoreceptors-->prolonged effective refractory period (TP-interval)

Class 3- amiodarone inhibit alpha and beta adrenergic-R- prolong TP segment- **CATEGORY D

Class 4- Verapamil- block calcium channel
Term
Hyperlipidemia drugs
Definition
Statin- lovastatin- competitive inhibition of HMG-CoA reductase in hepatocytes

Inhibit rate limiting enzyme in production of chol. and isoprenoids

Increase HDL, decrease LDL, decrease protein prenylation

***CATEGORY X
Term
Drugs for heart failure
Definition
Diuretics- loop or high celling- furosemide- inhibition of NKCC2 in TAL of loop of Henle in neophron

Positive ionotropics- Digoxin- inhibit Na/K ATPase in cardiac myofibril- increases intracellular calcium- decrease QT interval-->James bond
Term
Ischemia
Definition
Nitroglycerin- NO-->increase cGMP-->dephos. myosin light chain and decrease intracellular calcium-->relax smooth muscle Verapamil- block L-type Ca channels-->reduce transmembrane Ca current-->longer relaxation-->vasodilation
Term
Clonidin
Definition
a2 adrenoreceptors

Decreased CO, due to decreased HR, decreased capacitance of vessels, and decreased PVR/TPR
Term
Chlorothiozide
Definition
  • Diuretic
  • Inhibits Na/Ka co-transporter
  • Acts in DCT (distil convoluted tubule) in nephron
Term
Clonidine
Definition
  • Partial alpha-2 agonist
  • Acts on medulla (primary) and arterioles
  • Decreases CO
  • *Skin reactions due to patch
  • *Hypertensive crisis- WEAN patients off it
Term
Nitroprusside
Definition
  • Vascular smooth relaxation
  • Activates guanylyl cylase-->increases [cGMP]-->NO release
Term
Beta blocker
Definition

Propanolol

  • Hypertension and anti-arrythmia drug
  • B1 and B2 adrenoreceptor agonist of heart and kidney
  • Decreases CO
  • Blocks renin production
Term
Calcium channel blocker
Definition

Verapamil

  • Blocks L-type Ca channel in cardiac and smooth muscle cel mem
  • Decrease contractility
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