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Details

Cardio-Path
Clotting I, II, and III
34
Pathology
Graduate
09/26/2010

Additional Pathology Flashcards

 


 

Cards

Term
Clotting Problems not detected conventionally
Definition
Von Willebrand disease
Factor XIII deficiency
Alpha-2 antiplasm deficiency
Mild Deficiencies
Term
How is a aPTT administered
Definition
Ca, partial thromboplastin, activators to the plasma
Term
Vitamin K dependent factors
Definition
c,s,2,7,9,10
Term
Contents of Platelet Granules
Definition

Alpha: 1,4,5,8, PGDF, TGF-B

Dense: Ca, ADP, ATP, Serotonin, Bradykinin, Epinephrine

Term
Situations of Abnormal clotting testing without factor deficiencies
Definition
Vit K Deficiency, Warfarin, Liver Cirrhosis, DIC
Term
Physical cues of platelet or vascular disorders
Definition
Mucosal Bleeding, Petechiae, Certain Vascular Lesions
Term
Congenital Vascular Disorders
Definition

Hereditary Hemorrhagic Telengectasia(Oshler-Weber-Rondu)

Ehler-Danlos

Term
Causes of decreased platelet production
Definition
DRUGS/Radiation, Aplastic, Amegacytosis, marrow Replacement
TAR, B12/Folate Deficiency
Term
Causes of Platelet destruction
Definition
TTP, ITP
DIC, Sepsis, HIV, Marrow Biopsy
Term
Where is Von Willebrand factor found
Definition
Plasma, Alpha Granules, Weibel-Palade
Term
Diseases of Platelet Dysfunction
Definition
Glanzmans, Bernard-Soulier
Storage Pool, Grey Platelet, Prostaglandin
Term
Pentad of Thrombotic Thrombocytopenia Purpura
Definition
Thrombocytopenia, Microangiopahic Hemolytic Anemia, CNS, Fever, Renal Insufficiency
Term
Cause of TTP
Definition
Blockage of the metalloprotease for VWF
Term
When is Hemophilia A or B considered severe
Definition
< 1% of factor exists
Term
What is the treatment for hemophilia A or B
Definition
DDAVP which increases factor VIII
Term
What is the cause of Hemophilia C
Definition
Factor XI deficiency
Term
What are causes of Vitamin K deficiency
Definition
Malnutrition, Warfarin, Antibiotics/Newborn, Malabsorption
Term
TTP variant seen in children
Definition
Hemolytic Uremic Syndrome
Term
% of Hemophilia cases that are denovo mutations
Definition
25%
Term
Cues for a DVT Work-up
Definition
<45, odd location, Recurrent, Family History
Term
Signs of Homogeneous protein C deficiency
Definition
Cerebral Thrombus
Purpura Fulminans
Skin Necrosis
Term
Causes of acquired protein C deficiency
Definition
ARDS, Hormones
Liver, DIC, Surgery, Warfarin, Asparginase
Term
Epidemiology of Factor V Leiden
Definition
Scandinavian, Caucasian, 2-6%
Term
Mutation in V Leiden
Definition
Arg->Gln @ 506
Term
What Hypercoaguability is associated with Spanish poplulations
Definition
Prothrombin Mutation
Term
What is the function of factor C
Definition
Cleave Va and VIIIa
Term
Diagnosis of Antiphospholipid Syndrome
Definition
1 major+Positive Lupus Anticoag, Ig against Cardiolipin, Positive Snake Venom
Major: Thrombocytopenia, Thrombosis, Miscarriages
Minor: Derm Findings, Gangrene, Ulcers
Term
Treatment of Hyperhomocysteinemia
Definition
Folate, B12, B6
Term
Signs of Heparin induced Thrombocytopenia
Definition
Heparin Resistance
Platelet decrease after heparin use
Term
When would a heparin Induced Thrombocytopenia present
Definition
4-10 days after heparin use
Term
Where is Protein S synthesiszed
Definition
Endothelium
Term
Why does factor V leiden  make a patient hypercoaguable
Definition
Resists Protein C degradation
Term
When do signs of prothrombin mutation first appear
Definition
Around age 40
Term
What percentage of Lupus patients have Antiphospholipid Syndrome
Definition
20-40%
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