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Carbapenems
Carbapenems
15
Pharmacology
Professional
08/19/2012

Additional Pharmacology Flashcards

 


 

Cards

Term
MOA of carbapenems
Definition

inhibit bacterial cell well synthesis by binding to one or more pencillin - binding proteins (PBPs) which in turn inhibits the final transpeptidation step of petidoglycan synthesis in bacterial cell walls.

Term

Are carbapenems concentration dependent or time dependent killing.

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Definition
Time dependent killing.
Term
Name the carbapenems
Definition

Imipenem/Cilastatin (Primaxin)

Meropenem (Merrem)

Ertapenem (Invanz)

Doripenem (Doribax)

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Term
Brand name for Imipenem/Cilastatin
Definition
Primaxin
Term
What is the Cilastatin for in Primaxin
Definition
Prevent degredation
Term
Brand name for Meropenem
Definition
Merrum
Term
Brand name for Ertapenem
Definition
Invanz
Term
Brand name for Doripenem
Definition
Doribax
Term
Describe antibiotic activity of carbapenems
Definition

active against most gram (+), garm (-) and anaerboic pathogens.

 

No atypical coverage

 

Term
Name serious side effects
Definition

Seizures in elevated doses and those with renal impairment (mainly imipenem)

Term
Reduce dose of carbapenems in renal impairment?
Definition
Yes!
Term
Is it okay to use carbapenems in those with PCN allergies?
Definition
NO!
Term

Uricosuric agents (probenecid and allopurinol) can increase levels of carbepenems by interfering with renal excretion.

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Definition
Statement. Not a question.
Term

Carbapenems can decrease serum concentrations of valproic acid leading to a loss of seizure control.

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Definition
Statement. Not a question.
Term

Avoid concomitant use of imipenem with ganciclovir.

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Definition
Statement. Not a question.
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