Shared Flashcard Set

Details

Cancer
N/A
46
Medical
Graduate
01/21/2009

Additional Medical Flashcards

 


 

Cards

Term
Constant proportion of cell population killed rather than a constant number
Definition
Log-Kill hypothesis
Term
Treatment with cancer chemotherapy at high doses every 3-4 weeks, too toxic to be used continuously
Definition
Pulse therapy
Term
Toxic effect of anticancer drug can be lessened by rescue agents
Definition
Rescue Therapy
Term

 

Drug used concurrently with toxic anticancer agents to reduce renal precipitation of urate

Definition

Allopurinol

(Xanthine oxidase inhibitor) - inhibits purine oxidation, allowing purines to be excreted in a form more soluble

Increased cell lysis causes hyperuricemia

Term
Pyrimidine analog that causes 'Thymine-less death' given with leucovorin rescue
Definition

5-FU

(Pyrimidine antagonist, CCS - antimetabolite)

Term
Drug used in CA therapy causes Cushing-like symptoms
Definition
Prednisone
Term
SE of Mitomycin
Definition

Severe myelosuppression

Term
Mitomycin
Definition
Used for hypoxic tumor stem cells
Term
MOA of cisplatin
Definition
Alkylating agent
Term
Toxicities of cisplatin
Definition

Nephrotoxic and Ototoxic

(Hydration with IV saline reduces nephrotoxicity)

Severe interaction with aminoglycosides

Term
Agent similar to cisplatin, less nephrotoxic but greater myelosuppresion
Definition
Carboplatin
Term
Analog of hypoxanthine, needs HGPRTase for activation
Definition

6-MP

 

Term
Interaction with this drug requires dose reduction of 6-MP
Definition
Allopurinol
Term
Toxicities of Doxorubicin
Definition
myelosuppresion and cardiotoxicity
Term
May protect against doxorubicin toxicity by scavenging free radicals
Definition
Dexrazoxane
Term
Blows DNA (breaks DNA strands), limiting SE is pulmonary fibrosis
Definition
Bleomycin
Term
Alkylating agent, vesicant that causes tissue damage with extravasation (blisters)
Definition
Mechlorethamine
Term
Alkylating agent also used in RA, produces acrolein in urine that leads to hemorrhagic cystitis
Definition
cyclophosphamide
Term
Prevention of cyclophosphamide induced hemorrhagic cystitis
Definition
Hydration and mercaptoethanesulfonate (MESNA)
Term
Microtubule inhibitor that causes peripheral neuropathy, foot drop (ataxia) and 'pins and needles' sensation
Definition
Vincristine
Term
Interact with microtubules, stabalizes tubulin and cells remain frozen in metaphase
Definition
Paclitaxel (taxol)
Term
Inhibits Topoisomerate II, blocking cell division in late S-G2 phase
Definition
VP-16 (etoposide) or VM-26 (teniposide)
Term
Inhibits topoisomerase I, CCNS
Definition
Topotecan, Irinotecan (Camptothecins)
Term
Converts asparagine to aspartate and ammonia, denies cancer cells of essential AA (asparagine)
Definition
L-asparaginase
Term
Used for hairy cell leukemia; it stimulates NK cells
Definition
Interferon alpha
Term

 Antiandrogen used for prostate CA

Definition
Flutamide (Eulexin)
Term
Anti-estrogen used for estrogen receptor + breast CA
Definition
Tamoxifen
Term
Aromatase inhibitor used in breast CA
Definition

Letrozole, anastrozole

No inhibitory effects on adrenals

Term
Newer estrogen receptor antagonist used in advanced breast CA
Definition
Toremifene (Fareston)
Term
Nonsteroidal inhibitor of corticosteroid synthesis (cholesterol to pregnenolone) and aromatase inhibitor
Definition

Aminoglutethamide

Causes adrenal insufficiency

Term
GnRH analogs used in advanced prostate CA
Definition
Loeuprolide and goserelin
Term
CCS Drugs
Definition
Bleomycin, vinca alkaloids, antimetabolites (5-FU, 6-MP, MTX, etoposide)
Term
CCNS Drugs
Definition
Alkylating Agents (mechlorethamine, cyclophosphamide) antibiotics (doxorubicin, daunorubicin), cisplatin, nitrosurea
Term
Antiemetics used in association with anti-cancer drugs that are 5-HT3 antagonists
Definition
Odansetron, granisetron
Term
Nitrosureas with high lipophilicity, used for brain tumors
Definition
Carmustine (BCNU) and lomustine (CCNU)
Term
Produces disulfirarm-like reaction with ethanol
Definition
Procarbazine
Term
MOPP regimen used in Hodgkin's disease
Definition
Mechlorethamine + oncovorin (vincristine) + procarbazine + prednisone
Term
ABVD regimen used for HD, but appears less likely to cause sterility and secondary malignancies than MOPP
Definition
Adriamycin (doxorubicin) + bleomycin + vinblastine + dacarbazine
Term
Regimen used in non-Hodgkin's lymphoma
Definition
CHOP - cyclophosphamide, doxorubicin, oncovin (vincristine) and prednisone
Term
Regimen for Breast CA
Definition

CMF - Cyclophosphamide, methotrexate and 5-FU

(Tamoxifen if ER+)

Term
Inhibitor of tyrosine kinase domain of Bcr-Abl; used for CML
Definition
Imatinib
Term
Monoclonal Ab against domain of EGFR
Definition
Cetuximab
Term
Folic acid antagonist that binds to DHFR
Definition
Methotrexate
Term
Regimen used in treatment of advanced colorectal CA
Definition
FOLFOX (5-FU, Leucovorin, Oxaliplatin)
Term
Inhibits ribonucleotide reductase, which converts ribonucleotides to deoxyribonucleotides for DNA synthesis
Definition
Hydroxyurea
Term
Used for Insulinoma
Definition
Streptozocin
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