Shared Flashcard Set

Details

Cancer
Terms
24
Pathology
Undergraduate 1
12/20/2012

Additional Pathology Flashcards

 


 

Cards

Term
Transformation
Definition
Concersion from normal cell growth to unregulated growth
Term
proto-oncogenes
Definition
genes involved in normal growth and division
Term
oncogenes
Definition
cancer causing genes
Term
growth-stimulating pathway
Definition
normal cell division
Term
growth-factor receptor
Definition
activated which sends the message to stimulate growth
Term
Tyrosine kinase
Definition
growth-factor receptor
Term
G signaling protein
Definition
Activated growth factor receptors activate these which signal protein kinases
Term
Ras
Definition
G signaling protein
Term
Protein kinase
Definition
enzymes that activate a transcription factor
Term
Transcription factor
Definition
molecules that activate genes to initiate cell division
Term
Growth-inhibiting pathway
Definition
Normal cell division supression
Term
Growth inhibiting factor
Definition
the molecule that activates the pathway and stimulates suppression. When these bind to a surface receptor on the cell, protein kinases activate a transcription factor which in turn activates p53 to suppress growth
Term
Tumor
Definition
Aggregate of cells which has lost their ability to function properly
Term
Angiogenesis
Definition
Growth of blood cessels for the express purpose of supplying the cancer with nutrients
Term
Blood brain barrier
Definition
Tightly bound capillaries around the brain that don’t let anything (drugs) across
Term
G1 Checkpoint
Definition
first checkpoint in the cell cycle that determines if the cell can continue dividing or not.
Term
G0 Checkpoint
Definition
when a cell doesn’t pass a checkpoint, it is sent to the G0 resting phase where it can’t divide. some types of cells (liver, etc) can return to G1 if they are stimulated by growth factors
Term
G2 Checkpoint
Definition
stops growth before the cell begins mitosis (M phase)
Term
M Checkpoint
Definition
checkpoint that makes sure the spindle fibers in the cell are connected properly
Term
Cyclin
Definition
a protein that attaches to cyclin dependent kinases (CDK). cyclin concentration levels act as another cell division regulator
Term
MPF
Definition
Allows a cell to pass the G2 checkpoint and enter the M checkpoint
Term
CDK
Definition
kinase that requires cyclin to function. cyclin-CDK complex is called MPF
Term
RMP-7
Definition
Makes the BBB permeable
Term
Carboplatin
Definition
Active drug that is administered to brain
Supporting users have an ad free experience!