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Blood Dyscrasias
Buzz Words
16
Medical
Graduate
05/19/2009

Additional Medical Flashcards

 


 

Cards

Term
Acute Lymphoblastic Leukemia
Definition

Children (3-5 yrs)

 

Pancytopenia

h/o radiation tx

a/w Down's syndrome

Term
Acute Myelogenous Leukemia
Definition

>30 yrs

 

Pancytopenia

Auer Rods (cytoplasmic needles)

DIC

Term
Chronic Myelogenous Leukemia
Definition

30-50 yrs

 

WBC >50

Philadelphia Chromosome (t9;22)

Blast Crisis (-> ~AML)
Splenomegaly

Term
Chronic Lymphocytic Leukemia
Definition

>50 yrs

 

Males

Lymphadenopathy

Lymphocytosis (B cells)

Infections

Smudge cells (fragile; artifact of smearing)

Splenomegaly

Term
Hairy Cell Leukemia
Definition

Adults

 

Subtype of CLL

(Mature B cell neoplasm)

Splenomegaly

 

Hairy cytoplasmic projections from B cells

Term

Mycosis fungoides

(Sézary syndrome)

Definition

>50 yrs

 

Cutaneous CD4 T cell lymphoma (non-Hodgkin's)

Plaque-like, itchy skin rash; does not improve c tx

Smear: cerebriform (convoluted) nuclei

Pautrier miccroabscesses in epidermis

 

Clearly, not a fungus!

Term
Burkitt's Lymphoma
Definition

Children

 

B cells

c-myc translocation

"Starry sky" - macrophages c apoptic reside inside

a/w Epstein-Barr Virus

Term
CNS B-cell lymphoma
Definition

Adults

 

a/w HIV-AIDS

Ring-enhancing lesions on CT head

(ddx: toxoplasmosis)

 

Term
T-cell leukemia
Definition

Adults

 

Mature T cells

Cause - ?HTLV-1

Term
Hodgkin's Disease
Definition

15-34 yrs

 

B cell lymphoma

Reed-Sternberg Cells (binucleate B cells)

Cervical lymphadenopathy

Night sweats

Term
Non-Hodgkin's Lymphoma
Definition

Any age

 

Best prog: small follicular

Worst prog: large diffuse

Primary tumor: ?GI tract

Term

Myelodysplasia

Myelofibrosis

Definition

>50 yrs

 

 

Anemia

Teardrop RBCs

Dry tap on marrow bx

High MCV and RBC distribution width

a/w CML

Term
Multiple Myeloma
Definition

>40 yrs

 

Plasma cells

Bence Jones protein (urinary free light chains)

-------50% IgG, 25% IgA

Osteolytic lesions

RBC rouleaux

Hypercalcemia

Renal failure

Term
Waldenstrom's disease
Definition

>40 yrs

 

Hyperviscous serum

Monoclonal IgM spike

Cold agglutins (Raynaud's)

Chronic oozing from nose, gums

Term
Polycythemia vera
Definition

>40 yrs

 

High Hb

Pruritus s/p hot bath/shower

Tx: Phlebotomy

Term
Primary thrombocytopenia
Definition

>50 yrs

 

Platelets >1,000,000

Bleedings or thrombosis

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