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Block 1 957
PK/PD - davis
15
Science
Professional
09/10/2011

Additional Science Flashcards

 


 

Cards

Term
MIC
Definition
minimum inhibitory concentration (e.g. mg/mL), the least amount of drug that prevents visible growth of a predetermined number of organisms (usuallY 90%)
Term
AUC or AUC 0-24
Definition
good index of antibiotic exposure, and it depends directly on dose, but is influence by F and Cl
Term
AUC/MIC
Definition

remember MIC is always in vitro

(generally AUC is over 24 hours)

Term
AUIC (hrs)
Definition
area under the inhibitor curve using actual inhibitory titers
Term
Time > MIC
Definition
cumulative percentage of time over 24 hour period that the drug concetratione xceed the MIC at steady state conditions during the dosing interval
Term
PAE
Definition

measured in hours

reflects bacterial recovery time

can be in vitro or vivo

we know this exists but we can't be specific on how long the effect will be and which patient it will happen for

Term
concentration dependent killing
Definition

higher the conc, the greater the rate & extent of bactericidal activity

 

Cpk/MIC or AUC/MIC

 

AG, FQ, metronidazole

Term
minimal concentration or time-dependent killing
Definition

saturation of the killing rate occurs at low mulitples of the MIC - usually 4-5x

 

largely dependent on the time of exposure

t >MIC

 

eg. beta -lactams, vanc, clinda, macrolides

Term
beta - lactams
Definition
time dependent and bactercidal
Term
fluoroquinolones
Definition

typically bactericidal with concentration dependent killing

 

Cpk/MIC and AUC 0-24/mic

Term
aminoglycosides
Definition

exhibit concentration dependent killing for gram - bacteria

 

(possibly time dependent for gram + bacteria)

 

Cpk/mic ratio is most commonly linked to clinical outcomes

Term
vancomycin
Definition

exhibit time - dependent killing and usually bactericidal by inhibition of cell wall synthesis (therefore, the bacteria must be growing)

 

t>mic and possibly AUC/mic

 

PAE = 2-3 hours for gram +

 

Term
macrolides
Definition

generally bacteriostatic, clarith and azith are bactericidal agains S. pyogenes, S. pneumo, and H. flu

 

Term

erythromycin and clarithromycin

best predictor?

Definition
t>MIC
Term

azithromycin

best predictor?

Definition
best correlated with AUC0-24 hour/MIC
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