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Biology Ch 10, 12 and 13
Nelson's Biology
95
Biology
Undergraduate 1
11/14/2011

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Term
Was known to be a chemical in cells by the end of the nineteenth century

Has the capacity to store genetic information

Can be copied and passed from generation to generation
Definition
DNA
Term
DNA and RNA are _____ _____
Definition
nucleic acids.
Term
DNA and RNA consist of chemical units called
Definition
nucleotides
Term
nucleotides are joined by a ___-____ _____
Definition
sugar-phosphate backbone.
Term
The four nucleotides found in DNA differ in their nitrogenous bases. These bases are:
Definition
Thymine (T)

Cytosine (C)

Adenine (A)

Guanine (G)
Term
RNA has ____ in place of thymine.
Definition
Uracil (U)
Term
The model of DNA is like a ____ ______ ______ ____ __ _____
Definition
rope ladder twisted into a spiral.
Term
DNA bases pair in a complementary fashion...
Definition
Adenine (A) pairs with thymine (T)

Cytosine (C) pairs with guanine (G)
Term
When a cell reproduces, a complete copy of the ______ must pass from one _____ ___ ___ _____
Definition
DNA

generation to the next.
Term
DNA can be damaged by _______ _____
Definition
ultraviolet light.
Term
DNA functions as the ________ _____ for a cell or organism
Definition
inherited directions
Term
An organism’s _______ is its genetic makeup, the sequence of _______ _____ in DNA.
Definition
genotype

nucleotide bases
Term
The _________ is the organism’s physical traits, which arise from the actions of a wide variety of protines
Definition
phenotype 
Term
_______ specifies the synthesis of proteins in two stages: transcription and translation
Definition
DNA
Term
The function of a gene is to dictate the production of a _____
Definition
polypeptide
Term
A protein may consist of two or more different _____
Definition
polypeptides
Term
Genetic information in DNA is transcribed into _____ then
Translated into ________
Definition
RNA

Polypeptides
Term
In DNA, it is the linear sequence of nucleotide bases.
Definition
the language of nucleic acids
Term
A typical gene consists of thousands of _____
Definition
nucleotides.
Term
A single DNA molecule may contain thousands of _____
Definition
genes
Term
When DNA is transcribed, the result is an ______ ________
Definition
RNA molecule
Term
a triplet of bases, which codes for one amino acid ____
Definition
codon
Term
___ _____ is a set of rules relating nucleotide sequence to amino acid sequence

Shared by all organisms
Definition
genetic code
Term
Of the ___ triplets:

___code for amino acids One of these also serves as a start codon

____are stop codons, indicating the end of a _______
Definition
64

61

3

Polypeptide
Term
May Have a Variety of Effects on Protein Structure and Function

Provide the Raw Material for Evolution and are changes in the base sequence of DNA
Definition
Mutations
Term
Most mutations are categorized as ____ ______ _____ _____ _____
Definition

Substitutions Translocation Deletions Insertions Inversions

 

(S T D II)

 

 

Term
_____ in the DNA base sequence are transcribed into the mRNA and translated into a different amino acid sequence in the protein.
Definition
Mutations
Term
Mutations create new ___ ______ and are the ultimate source of genetic variation, those that are beneficial may spread through a population and become common
Definition
gene sequences
Term
____ _______ is the analysis of DNA samples that can be used to determine whether the samples come from the same individual.
Definition
DNA profiling
Term
________is the manipulation of organisms or their components to make useful products
Definition
Biotechnology
Term
Biotechnology today means the use of _____ ______ methods for:
Studying and manipulating genetic material
Modifying specific genes
Moving genes between organisms
Definition
DNA technology
Term
_____ ____is formed when scientists combine nucleotide sequences (pieces of DNA) from two different sources to form a single DNA molecule
Definition
Recombinant DNA
Term
Recombinant DNA technology is widely used in _______ _____ the direct manipulation of genes for practical purposes.
Definition
genetic engineering
Term
In 1982,_______ the world’s first genetically engineered pharmaceutical product was sold.
Definition
Humulin / Human insulin
Term
DNA technology is used to produce medically valuable molecules, including: (3 things)
Definition
Human growth hormone (HGH)

The hormone EPO, which stimulates production of red blood cells

Vaccines
Term
_______, harmless variants or derivatives of a pathogen used to prevent infectious diseases
Definition
Vaccines
Term
Scientists have produced many types of ___ ___ ___ organisms that have acquired one or more genes by artificial means
Definition
genetically modified (GM) organisms
Term
_____ _____contains a gene from another organism, typically of another species.
Definition
transgenic organism
Term
Bacteria are the workhorses of modern ______
Definition
biotechnology
Term
To work with genes in the laboratory, biologists often use bacterial _____ small, circular DNA molecules that are separate from the much larger bacterial chromosome
Definition
plasmids
Term
______ can easily incorporate foreign DNA:

Are readily taken up by bacterial cells

Can act as vectors

Are ideal for gene cloning
Definition
Plasmids
Term
Recombinant _____ _____ can help biologists produce large quantities of a desired protein.
Definition
DNA techniques
Term
_____ ______ can be used to determine if two samples of genetic material are from a particular individual
Has rapidly revolutionized the field of ______, the scientific analysis of evidence from crime scenes
Definition
DNA Profiling

Forensics
Term
To produce a DNA profile, scientists compare ______ ______sequences in the genome that vary from person to person.
Definition
genetic markers
Term
_______ is the science of studying complete sets of genes .
Definition
Genomics
Term
The first targets of genomics were
Definition
bacteria
Term

Begun in 1990, the ___ ___ ___ was a massive scientific endeavor:

To determine the nucleotide sequence of all the DNA in the human genome and to identify the location and sequence of every gene

Definition
Human Genome Project
Term
The Human Genome Project can help map the genes for specific diseases such as:
(2 diseases)
Definition
Alzheimer’s disease

Parkinson’s disease
Term
Begun in 2006, the ____ ____ _____ seeks to collect information on all of the genetic variations that affect human health
Definition
Human Variome Project
Term
As soon as scientists realized the power of DNA technology, they began to worry about potential dangers such as the:
Definition
Creation of hazardous new pathogens

Transfer of cancer genes into infectious bacteria and viruses
Term
Strict laboratory safety procedures have been designed to:

Protect researchers from infection by ____ _____

Prevent_________ from accidentally leaving the laboratory
Definition
engineered microbes

Microbes
Term
__ strains account for a significant percentage of several agricultural crops in the United States.
Definition
GM
Term
Darwin presented two main concepts: ___ _______

Change occurs as a result of __ ___ ___ with natural selection as the mechanism
Definition
Life evolves

“descent with modification,”
Term
_____ _____ is a process in which organisms with certain inherited characteristics are more likely to survive and reproduce than are individuals with other characteristics and leads to a population
Definition
Natural Selection
Term
In one modern definition of ________ the genetic composition of a population changes over time.
Definition
evolution
Term
The ______ ___ ______ challenged the notion that the Earth was: relatively young and Populated by unrelated species.
Definition
Origin of Species
Term
The Greek philosopher _______ held the belief that species are fixed and do not evolve.
Definition
Aristotle
Term
___ ____ ___suggested that organisms evolved by the process of adaptation by the inheritance of acquired characteristics, now known to be incorrect
Definition
Jean Baptiste Lamarck
Term
___ ___dropped out of medical school and then studied for the clergy at Christ's College at Cambridge
Sailed on the Beagle
Definition
Charles Darwin
Term
Darwin was intrigued by:

The _______ ______ of organisms on the Galápagos Islands and

_________between organisms in the Galápagos and those in South America
Definition
geographic distribution

Similarities
Term
Darwin was strongly influenced by the writings of geologist ______ _____
Definition
Charles Lyell
Term
Lyell suggested that the Earth:

Is____ _____

Was sculpted by gradual ______ ______ that continue today
Definition
very old

geological processe
Term
Dawin was also influenced by _____ _____ who wrote Essay on Populations

__________ are limited by the resources available which leads to competion.
Definition
Thomas Malthus

Populations
Term
Darwin made two main points in ___ ____ _______:

Organisms inhabiting Earth today descended from _____ species

_____ ______ was the mechanism for descent with modification
Definition
The Origin of Species

ancestral

Natural selection
Term
Types of biological evolution that leave observable signs.
Definition

Molecular biology, Comparative embryology, Comparative anatomy, Biogeography, and the fossil record

M C C B F

(Moms Cat Can Barely Fly)

Term
______ Record Is the ordered sequence of _______ as they appear in rock layers

Reveals the appearance of organisms in a historical sequence

Fits the molecular and cellular evidence that prokaryotes are the ancestors of all life
Definition
Fossil
Fossils
Term
________ are scientists that study fossils
Definition
Paleontologist
Term
___________ is the study of the geographic distribution of species that first suggested to Darwin that today’s organisms evolved from ancestral forms.
Definition
Biogeography
Term
____ ____ Is the comparison of body structure between different species

Confirms that evolution is a remodeling process
Definition
Comparative anatomy
Term
The similarity in structures due to common ancestry
Illustrated by the remodeling of the pattern of bones forming the forelimbs of mammals
Definition
Homology
Term
_____ ______ are remnants of features that served important functions in an organism’s ancestors
Definition
Vestigial structures
Term
Early stages of development in different animal species reveal additional homologous relationships.

Ex: pharyngeal pouches appear on the side of the embryo’s throat, which:
Develop into gill structures in fish
Form parts of the ear and throat in humans
Definition
Comparative Embryology
Term
The hereditary background of an organism is documented in
Definition
Its DNA
Term
Evolutionary relationships among species can be determined by comparing:

_____ and

________ of different organisms
Definition
Genes

Proteins
Term
All species tend to produce excessive numbers.
This leads to a struggle for existence.
Definition
Overproduction
Term
_____ variation exists among individuals in a population. Much of this variation is heritable.
Definition
Individual
Term
Genetic variation results from:

_______ ______the shuffling of alleles during meiosis and Mutations
Definition
Sexual recombination
Term
Darwin saw the history of life as analogous to a
Definition
tree
Term
_____ _____ is the fusion of genetics with evolutionary biology
Definition
modern synthesis
Term
A group of individuals of the same species, living in the same place, at the same time
The smallest biological unit that can evolve
Definition
population
Term
Individual variation abounds in ________

Not all variation in a population is ______

Only the genetic component of variation is relevant to ____________
Definition
populations

heritable

natural selection
Term
Variable traits in a population may be:

______ resulting from the combined effects of several genes or determined by a single gene
Definition
Polygenic
Term
traits tend to produce phenotypes that vary more or less continuously.
Definition
Polygenic traits
Term
_____ ____traits tend to produce only a few distinct phenotypes.
Definition
Single gene
Term
____ ____is a reservoir from which the next generation draws its genes.
Definition
gene pool
Term
From a genetic perspective evolution can be defined as a generation-to-generation change in a population’s frequencies of alleles, sometimes called ___________
Definition
microevolution.
Term
The main causes of evolutionary change are:

_____ _____

_____ _____

_____ ______
Definition
Genetic drift

Gene flow

Natural selection
Term
A change in the gene pool of a small population
Due to chance.
Definition
genetic drift
Term
____ _____ Is an example of genetic drift
Results from a drastic reduction in population size
Definition
bottleneck effect
Term
____ ______is likely when a few individuals colonize an isolated habitat and represent genetic drift in a new colony.
Definition
Founder effect
Term
____ _____ Is genetic exchange with another population
Tends to reduce genetic differences between populations
Definition
gene flow
Term
_________ DNA carriers that move genes from one cell to another
Definition
vectors
Term
____ ____ the production of multiple identical copies of a gene-carrying piece of DNA
Definition
gene cloning
Term
______ the transfer of genetic information from DNA into an RNA molecule
Definition
transcription
Term
_________ the transfer of information from RNA into a protein
Definition
translation
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