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Biochemistry 2 Final Review
Review for the final exam of biochem 2
27
Chemistry
Undergraduate 2
02/22/2009

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Cards

Term
What enzyme is a control point of catabolic flux?
Definition
Pyruvate Dehydrogenase Complex (Pyruvate DH)
Term
The Coenzyme Q Redox center acts as...
Definition
A gateway between two electron and one electron acceptors
Term
what compound inhibits the synthesis of ATP from oxidative phosphorylation by blocking electron flow at complex III?
Definition
antimycin
Term
The Malate-Aspartate shuttle allows
Definition

transfer of oxaloacetate (as aspartate) across the membrane

transfer of NADH across the inner membrane

Transfer of reducing equivalents across the membrane

replenishment of oxaloacetate.

Term
The enzymes that catalyze a reaction that directly replenishes oxaloacetate are...
Definition

Malate Dehydrogenase (Malate DH)

Pyruvate Carboxylase

Pyruvate Dehydrogenase

Term
The pentose phosphate pathway generates ___ for use in anabolic reactions and occurs when there's a large excess of ___
Definition

NADPH

G6P

Term
Cytochrome P450 _____ with drug activity, ____ compounds, both _____ enzyme activity and ____ solubility
Definition
Hydroxylating

altering

increasing

Term
deficincy of pyruvate carboxylase would ___ gluconeogenesis
Definition
inhibit
Term
Acetyl-CoA combines with ___ to form citrate
Definition
Oxaloacetate
Term
An animal with the UCP-1 protein would...
Definition
Generate excess heat and have lower energy levels
Term
triclosan is....
Definition
an antibacterial that inhibits fatty acid biosynthesis
Term
Starting metabolites for faty biosynthesis are activated by ___
Definition
ACP
Term
lipoproteins formed in the intestinal mucosal cells are called...
Definition

Chylomicrons

Term
___has 6 active sites that catalyze different reactions in FA biosynthesis
Definition
Eukaryotic fatty acid synthase
Term
Malonyl CoA ACP transacyclase is not found in....
Definition
the liver
Term
CoA dehydrogenase is found...
Definition
inside the mitochondria
Term
beta-oxidation of fatty acids is inhibited by...
Definition
malonyl CoA
Term
Patients with CPT II deficiency...
Definition
do not make enough acetyl CoA
Term
UCP-1 will cause...
Definition
exercise tolerance
Term
ALA synthase is inhibited by...
Definition
Heme
Term
thymidylate synthase is inhibited by
Definition
5-fluorouracil
Term
inhibition of HMG CoA reductase would result in...
Definition
increased uptake of LDL particles by cells
Term
Thymidylate synthase is important in...
Definition
DNA synthesis and as a target in cancer therapy
Term
Initiation of DNA Replication requires...
Definition
mechanism that binds initiation proteins, and generates a Tus Binding
Term
RNA polymerase subunit A is responsible for...
Definition
initiation, interaction with regulatory proteins, and acts as a promoter
Term
RNA polymerase B is responsible for
Definition
initiation and enlongation
Term
RNA polymerase subunit B' is used for
Definition
DNA binding
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