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autocoids
N/A
39
Pharmacology
Graduate
08/19/2009

Additional Pharmacology Flashcards

 


 

Cards

Term
Alprostadil
Definition

PGE1 anaolog used to dilate ductus arteriosis to increase pulmonary blood flow and oxygenation

 

also used locally to promote erection

Term
Epoprostenol; Flolan
Definition
PGI2 anaolg used for relief of pulmonary hypertension, and severe PVD. improves harvest and storage of platelets. used as a substitute for heparin during dialysis
Term
Carbacyclin
Definition
PGI2 analog used for anticoagulation effects.
Term
Iloprost
Definition

PGI2 analog used for anticoagulation effects.

also used for supression of gastric ulceration

Term
Beraprost
Definition
PGI2 analog used for anticoagulation effects.
Term
Trepostinil
Definition
PGI2 analog used for anticoagulation effects.
Term
Actions of PGE2 in cardiovascular system
Definition
Lowers BP by direct dilation of coronary vessels, decreasing NE release, and attenuation of ADH, AGII, etc. Suppresses arrhythmias and decreases free oxygen radical generation.
Term
PGE2 actions in the Renal system
Definition

veno-vasodilation by directly decreasing vascular resistance and increases renal blood flow. promotes natriuresis, kaluresis and decreases CL- reabsorption.

decreases action of vassopressin on collecting duct permeability to water.

increases renin secretion

Term
Actions of PGI2 in cardiovascular system
Definition

Lowers BP by direct dilation of coronary vessels, decreasing NE release, and attenuation of ADH, AGII, etc. Suppresses arrhythmias and decreases free oxygen radical generation.

 

inhibits platelet aggregation in endothelial cells

Term
PGI2 actions in the Renal system
Definition

veno-vasodilation by directly decreasing vascular resistance and increases renal blood flow. promotes natriuresis, kaluresis and decreases CL- reabsorption, but not as much as PGE2

increases renin secretion

Term
PGE2 actions in the respiratory system
Definition
dilate bronchioles
Term
PGI2 actions in the respiratory system
Definition
dilates bronchioles
Term
PGI2 actions in the gastrointestinal system
Definition
decreases gastric acid and pepsin secretion.
Term
PGE2 actions in the gastrointestinal system
Definition
decreases gastric acid and pepsin secretion. contracts longitudinal smooth muscle and may shorten GI transit time
Term
PGE2 actions in the reproductive system
Definition

relaxes non-pregnant uterus but contracts pregnant uterus

induces abortion and decreases postpartum hemorrhage

Term
PGF actions in the reproductive system
Definition

contracts pregnant and non-pregnant uterus

causes regression of corpus luteum

induces abortion and decreases postpartum hemorrhage

Term
PGF actions in the respiratory system
Definition
constrics bronchioles
Term
PGF actions in the gastrointestinal system
Definition
contracts longitudinal smooth muscle and may shorten GI transit time
Term
TxA2 actions in cardiovascular system
Definition
increases BP, stimulates platelet aggregation, constricts coronary vessels
Term
TxA2 actions in respiratory system
Definition
constricts bronchioles
Term
PGD2 actions in the CNS
Definition
produces skin flushing and is released by nicotinic acid from epidermal Langerhans cells 
Term
PGE2 actions in nervous system
Definition

causes hyperthermia, induces fever in CNS

sensitizes nerve endings to pain from chemical and mechanical stimuli causing hyper algesia

Term
PGE2 actions in ANS
Definition
decrease NE release and decreases constriction of lood vessels by NE, AGII, and vasopressin
Term
PGI2 actions in the ANS
Definition
decrease NE release and decreases constriction of lood vessels by NE, AGII, and vasopressin
Term
PGE2 effects on metabolism
Definition
decrease basal and catecholamine induced lipolysis in adipose tissue and heart
Term
PGI2 effects on metabolism
Definition
decrease basal and catecholamine induced lipolysis in adipose tissue and heart
Term
Riprostil
Definition
PGE1 analog for supression of gastric ulceration
Term
Misoprostol
Definition
PGE1 analog for supression of gastric ulceration
Term
Dinoprost
Definition
PGF analog used to induce labor and abortion
Term
Dinoprostone
Definition

PGE2 analog used to induce labor and abortion

also used for dilation of cervix for uterine examination

Term
Carbaprost
Definition
15-methyl-PGF analog used to induce labor and abortion
Term
PGI2 actions in the peripheral nervous system
Definition
sensitizes nerve endings to pain from chemical and mechanical stimuli causing hyper algesia
Term
Latanoprost, Xalatan
Definition
PGF analog used for reducing resistance caused by hydrostatic pressure of uveoscleral outflow in glaucoma patients
Term
Bimatoprost
Definition
PGF analog used for increasing eyelash length, thickness, and darkness in patients with hypotrichosis of the eyelashes
Term
Aprotinin
Definition
Kallikrein inhibitor, natural protinease inhibitor, ihibits mediators of the inflammatory response, fibrinolysis, and thrombin generation during bypass surgery. used to reduce blood loss during bypass surgery
Term
Nesiritide
Definition
recombinant form of human BNP causes natriuresis, diuresis, dilates vascular smooth muscle in veins and arteries, decrease central venous pressure, inhibits aldosterone synthesis. used to treat dyspnea in CHF
Term
Bosentan
Definition
Endothelin receptor antagonist. blocks ET1 A and B receptor. used for treatment of pulmonary hypertension. can cause hepatotoxicity and peripheral edema
Term
Sitaxentan
Definition
Endothelin receptor antagonist. blocks ET1 A  receptor. used for treatment of pulmonary hypertension. can cause hepatotoxicity, flushing, and may interact with warfarin
Term
Ambrisentan
Definition
Endothelin receptor antagonist. blocks AT1 receptor. used for treatment of pulmonary hypertension. can cause flushing, hepatotoxicity (less than others)
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