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Atypical antipsychs and Lithium
Pharmacology
25
Medical
Professional
01/21/2012

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Cards

Term
This anti-psych causes agranulocytosis
Definition
clozapine
Term
clinical use of clozapine
Definition
manic depressive disorder not responsive to lithium
Term
PCKN of clozapine
Definition
No severe extrapyramidal nor hyperprolactinemia

D4 receptor
does NOT affect GABA synthesis
blocks Serotonin
Term
Side effects of clozapine
Definition
orthastatic hypotension
GI disturbances
excessive salivation at night
FATAL AGRANULOCYTOSIS
Term
contra's of clozapine
Definition
bone marrow dz
leukopenia
carbamazepine
Term
Multiple receptor anti psychs
Definition
risperidone, olanzapine, quetiapine, ziprasidone
Term
mech of action of multiple receptor antipcyhs
Definition
D2 and Serotonin receptors
Term
this is increased by 50% when taken w/a meal
Definition
Ziprasidone
Term
half lifes of multiple receptors longest to shortest
Definition
olanzapine, ziprasidone and quetiapine
Term
side effects of risperidone
Definition
asthenia
hyperprolactinemia
**sexual dysfunction**
Term
side effect of olanzapine
Definition
somnolence, constipation, akathisia
**sexual dysfunction**
extrapyramidal symptoms
Term
quetiapine side effects
Definition
increase in QT interval
increase in aminotransferase
tardive dyskinesis
Term
ziprasidone effects
Definition
least amt of weight gain
prolonged QT interval
Term
mechanism of aripiprazole
Definition
partial D2 and 5-HT agonism

partial antag on 5-HT b rec
Term
metabolism of aripiprazole
Definition
CYP3A4 and CYP2D6
Term
adverse effects of aripiprazole
Definition
No extra-pyramidal
No prolactinemia, lipidemia, or weight gain
Term
clinical use if aripiprazole
Definition
schizo w/o extra-pyramidals
Term
compared to first generation, which has higher extra pyrmidal and weight gain
Definition
first- higher extra pyramidal

second- higher weight gain
Term
clinical use of Lithium carbonate
Definition
bipolar depression
acute manic attacks
manic depressive
Term
mech of action for Li Carbonate
Definition
competes with Mg binding
decrease IP3 and DAG
Term
adverse effects of Li carbonate
Definition
decreased thyroid function
polydipsia and polyuria
cognitive blunting
**do NOT breastfeed**
Term
drug interactions w/Li carbonate
Definition
thiazide diuretics- increased reabsorp ot Li

NSAIDs decrease elimination of LI
Term
use Li in caution with who
Definition
pregnancy and low Na diet
Term
this is given when patients do not respond to Li
Definition
Carbamazepine
Term
advantage of Valproic acid over Li
Definition
fewer side effects
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