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Antiviral Drugs 1
Pharmacology Exam 2
39
Pharmacology
Professional
04/18/2010

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Cards

Term
What is the mechanism of action of Immune Globulin?
Definition
Passive Immunity increased.

Prevention of infectious diseases in susceptible individuals.
Term
What are the indications of use for Immune Globulin?
Definition
Prevention of measles and hepatitis A.

Prophylactic use for prevention of measles and hepatitis B.
Term
What are the Main Toxicities of Immune Globulin?
Definition
Mild Toxicities- ingredients of formulations.
Term
What is the mechanism of action for Rabies Immune Globulin?
Definition
Antibody neutralizes virus-inhibits pathogenesis.
Term
What is the indication for use of Rabies Immune Globulin?
Definition
Passive Immunity to rabies virus.
Term
What are the main toxicities of the rabies immune globulin?
Definition
Local tenderness and stifness.

Systemic anaphylaxis after IV administration.
Term
What is the mechanism of action of Varicella-Zoster immune globulin?
Definition
Antibody neutralizes varicella-zoster virues-inhibits pathogenesis.
Term
What is the indication for use of varicella-zoster immune globulin?
Definition
Passive immunity to varicella and herpes zoster.
Term
What are the main toxicities of the Varicella-zoster immune globulin?
Definition
Local tenderness and irritation.

Systemic anaphylaxis after IV administration.
Term
What is the mechanism of action for the Hepatitis B Immune Globulin?
Definition
Antibody neutralizes the hepatitis B virus.
Term
What is the indication for use of the Hepatitis B immune globulin?
Definition
Passive Immunity to hepatitis B.
Term
What are the main toxicities of the Hepatitis B immune globulin?
Definition
Local tenderness and stiffness.

Anaphylaxis after IV administration.
Term
What is the mechanism of action of amantadine?
Definition
Blocks penetration and uncoating of virus.
Term
What is the indication for use of amantadine?
Definition
Influenza A virus.
Term
What are the main toxicities of amantadine?
Definition
CNS effects
Term
What is the mechanism of action of Ribavirin?
Definition
DNA and RNA synthesis inhibition.
Term
What are the indications of use for ribavirin?
Definition
Respiratory Syncytial Virus

Hepatitis C Virus (In combination with interferon alpha)
Term
What are the main toxicities of Ribavirin?
Definition
Teratogenesis
Term
What is the mechanism of action of Zanamivir?
Definition
Neurominidase Inhibitor
Term
What are the indications for use of Zanamivir?
Definition
Influenza A and B
Term
What are the main toxicities of Zanamivir?
Definition
Nasal and throat discomfort.
Term
What is the mechanism of action of oseltamivir?
Definition
Neuraminidase inhibitor.
Term
What are the indications for use of Oseltamivir?
Definition
Influenza A and B
Term
What are the main toxicities of Oseltamivir?
Definition
Nausea and Vomiting and Headache.
Term
What is the mechanism of action of Trifluridine?
Definition
DNA synthesis inhibition. (viral and cellular)
Term
What is the indication for use of Trifluridine?
Definition
Herpes Simplex Keratitis.
Term
What are the main toxicities of Trifluridine?
Definition
Teratogenic.

Visual Haze.
Term
What is the mechanism of action of IFN-a-2a?
Definition
Viral Protein and Replication Inhibition.
Term
What is the indication for use of IFN-a-2a?
Definition
Genital and Anal Warts.

Hepatitis B

Hepatitis C and Ribavirin.
Term
What are the main toxicities of IFN-a-2a?
Definition
Flu Like Syndrome.

Myalgia

Transient Hematologic.
Term
What is the mechanism of action of Acyclovir?
Definition
DNA synthesis inhibition.
Term
What are the indications of use for Acyclovir?
Definition
Mucosal, Cutaneous, or Systemic Herpes simplex

Genital Herpes

Varicella Zoster
Term
What are the main toxicities for Acyclovir?
Definition
NON-TOXIC
Term
What is the mechanism of action for Gancyclovir?
Definition
DNA synthesis inhibition.
Term
What is the indication for Gancyclovir?
Definition
Cytomegalovirus Retinitis
Term
What are the main toxicities of Gancyclovir?
Definition
Teratogenic.

Myelosuppresion.

Neutropenia.
Term
What is the mechanism of action of Foscarnet?
Definition
DNA synthesis inhibition.
Term
What are the indications for foscarnet?
Definition
Cytomegalovirus retinitis in AIDS patients.
Term
What are the main toxicities of Foscarnet?
Definition
Renal.
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