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Antimuscarinic Drugs
Drugs to Know for Exam 2
14
Pharmacology
Graduate
10/10/2010

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Term
atropine (AKA hyoscyamine and analogs)
Definition
ACh/Muscarinic Antagonists
racemic mixture of d, l-hyoscyamine. The l isomer is pharmacologically more active.
Homotropine is a semisynthetic analog of atropine
Term
scopolamine (AKA hyoscine and analogs)
Definition
ACh/Muscarinic Antagonists
Methscopolamine is a quaternary analog that does not cross the blood-brain barrier
pharmacologic effects and uses of scopolamine are generally similar to those of atropine except it has more of a CNS depressant effect (sedation and amnesia) than atropine
prevention of motion-sickness and vertigo
Term
dicyclomine (Bentyl)
Definition
ACh/Muscarinic Antagonists
nonquaternary antimuscarinic agent
intestinal antispasmodic for the treatment of irritable bowel syndrome
Term
propantheline (Pro-Banthine)
Definition
ACh/Muscarinic Antagonists
antispasmodic effects (eg in the treatment of irritable bowel syndrome)
quaternary compound with few CNS effects
Term
glycopyrrolate (Robinul)
Definition
ACh/Muscarinic Antagonists
quaternary antimuscarinic agent (no CNS effects)
in anesthesiology as a preop medication to dry respiratory secretions and inhibit vagal reflexes
general purpose antimuscarinic agent
Term
ipratropium (Atrovent)
Definition
ACh/Muscarinic Antagonists
quaternary salt administered by inhalation for the treatment of asthma and COPD
few systemic effects
Term
tiatropium (Spiriva
Definition
ACh/Muscarinic Antagonists
quaternary salt administered by inhalation for the treatment of asthma and COPD
few systemic effects
Longer duration of action
Term
benztropine (Cogentin)
Definition
ACh/Muscarinic Antagonists
centrally acting antimuscarinics used in the treatment of Parkinson's disease or drug-induced Parkinsonism
Term
trihexyphenidyl (Artane)
Definition
ACh/Muscarinic Antagonists
centrally acting antimuscarinics used in the treatment of Parkinson's disease or drug-induced Parkinsonism
Term
tolterodine (Detrol)
Definition
ACh/Muscarinic Antagonists
urinary incontinence due to over active bladder.
Term
oxybutynin (Ditropan)
Definition
ACh/Muscarinic Antagonists
Term
fesoterodine (Toviaz)
Definition
ACh/Muscarinic Antagonists
urinary incontinence due to over active bladder.
Term
tropicamide (Mydriacyl)
Definition
ACh/Muscarinic Antagonists
used to dilate the pupil for opthamologic examination
Term
solifenacin (VESIcare)
Definition
ACh/Muscarinic Antagonists
urinary incontinence due to over active bladder.
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