Shared Flashcard Set

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Antihyperlipidemics
Fitz/Ardley (PDA II) Exam II
18
Pharmacology
Professional
02/06/2011

Additional Pharmacology Flashcards

 


 

Cards

Term

 

 

 

 

HMG-CoA Reductase Inhibitors

(Statins)

Definition

Lovastatin (Mevacor®)

Simvastatin (Zocor®)

Pravastatin (Pravachol®)

Fluvastatin (Lescol®)

Rosuvastatin (Crestor®)

Atorvastatin (Lipitor®)

Pitavastatin (Livalo®)

 

MOA: Block the synthesis of cholesterol through inhibition of HMG-CoA Reductase

 

Lowers LDL, Raises HDL

Term

 

 

 

 

Lovastatin

Definition

Mevacor®

 

 

 

 Dose: 10 mg

 

  

HMG-CoA Reductase Inhibitors (Statins)

Term

 

 

 

 

Simvastatin

Definition

Zocor®

 

 

 

 Dose: 10 mg

 

 

 HMG-CoA Reductase Inhibitor (Statin)

Term

 

 

 

 

Pravastatin

Definition

Pravachol®

 

Dose: 20 mg 

 

 Only statin that is not metabolized through CYP450

  

 

HMG-CoA Reductase Inhibitor (Statin)

Term

 

 

 

 

Fluvastatin

Definition

Lescol®

 

 

 

Dose: 10 mg 

 

  

HMG-CoA Reductase Inhibitor (Statin)

Term

 

 

 

 

Rosuvastatin

Definition

Crestor®

 

 

 

 Dose: 5 mg

 

  

HMG-CoA Reductase Inhibitor (Statin)

Term

 

 

 

 

Atorvastatin

Definition

Lipitor®

 

 

 

Dose: 10 mg 

 

 

 

HMG-CoA Reductase Inhibitor (Statin)

Term

 

 

 

 

Pitavastatin

Definition

Livalo®

 

 

 

Dose: 4 mg

  

 

HMG-CoA Reductase Inhibitor (Statin)

Term

 

 

 

 

Fibric Acid Derivatives

Definition

Gemfibrozil (Lopid®)

Fenofibrate (Tricor®)

 

MOA: Act at the site of peroxisome proliferator activated receptor (PPAR)

 

Lower Triglycerides, LDL, and Raise HDL (To a lesser extent than the statins)

Term

 

 

 

 

Gemfibrozil

Definition

Lopid®

 

 

 

 

 

 

 

Fibrinic Acid Derivative

Term

 

 

 

 

Fenofibrate

Definition

Tricor®

 

 

 

 

 

 

 

Fibrinic Acid Derivative

Term

 

 

 

 

Niacin

 

Definition

Niaspan®

 

 

Vitamin B3

 

MOA: Not Known  

 

Niacin

Term

 

 

 

 

Bile Acid-Binding Resins

(Bile Acid Sequestrants)

Definition

Cholestyramine (Cuemid®, Questran®)

Colestipol (Colestid®)

Colesevelam (Welchol®)

 

MOA: Binds with bile acids in the GI tract to decrease fat absorption

 

Decreased Triglycerides

Term

 

 

 

 

Cholestyramine

Definition

Questran®, Cuemid®

 

 

 

 

 

 

 

Bile Acid Sequestrant

Term

 

 

 

 

Colestipol

Definition

Colestid®

 

 

 

 

 

 

 

Bile Acid Sequestrant

Term

 

 

 

 

Colesevelam

Definition

Welchol®

 

 

 

 

 

Bile Acid Sequestrant

Term

 

 

 

 

2-Azetidinone

Definition

Ezetimibe (Zetia®)

 

 

MOA: Inhibits cholesterol absorption at small intestine brush border

 

Lowers LDL and Triglycerides, Raises HDL (slightly)

Term

 

 

 

 

Ezetimibe

Definition

Zetia®

 

 

 

 

 

 

2-Azetidinone

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