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Antiepileptic Drugs
fr. Gelb's lecture
8
Medical
Graduate
11/15/2012

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Cards

Term
Phenytoin (Dilantin)
Definition
Complex kinetics
Many drug interactions
Gingival hyperplasia
Hirsutism (excessive hairyness for fems)
Rash (sometimes serious), osteoporosis
Cerebellar damage with long use
Term
Carbamazepine (Tegretol)
Definition
Drug interactions (note: erythromycin reduces carbamazepine clearance - potential toxicity)
Neutropenia, hyponatremia, rash, osteoporosis
Term
Valproate (Depakote)
Definition
Hepatic enzyme (CP450) inhibitor
Drug interations
Weight gain
Tremor
Alopecia
Thrombocytopenia
Panreatitis
Hyperammonemia
Term
Gabapentin (Neurontin)
Definition
No drug interactions
Weight gain
peripheral edema
Term
Pregabalin (Lyrica)
Definition
Prodrug
No drug interactions
Weight gain
Peripheral edema
Term
Lamotrigine (Lamictal)
Definition
Broad spectrum
Slow to load
Rash (may be life threatening)
Term
Topiramate (Topamax)
Definition
Weight loss
Metabolic acidosis
Kidney stones
Cognitive slowing, word-finding difficulty
Glaucoma (rare)
Term
Levetiracetam (Keppra)
Definition
Broad spectrum
No drug-drug interactions
Behavioral problems
Rare psychosis
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