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Antidiabetics
Part 4
25
Nursing
Graduate
11/17/2014

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Cards

Term
WHAT IS THE MECHANISM OF ACTION OF THIAZOLIDINEDIONES (TZDS)?
Definition
PPAR (GAMMA) INCREASE THE SENSITIVITY OF INSULIN IN TISSUES. WORKS SIMILAR TO FIBRATES TO LOWER LIID LEVELS. MAIN EFFECT IS THE CHANGE GENE REGULATION.
Term
WHAT IS THE ONSET OF THIAZOLIDINEDIIONES (TZDS)?
Definition
DUE TO MOA, ONSET CAN BE WEEKS TO MONTHS
Term
TZDS CAN BE BENEFICIAL IN THE PREVENTION OF WHAT?
Definition
DMII
Term
NAME 2 TZDS?
Definition
ROSIGLITAZONE AND PIOGLITAZONE (ACTOS)
Term
ROSIGLITAZONE IS RESTRICTED DIE TO WHAT?
Definition
CV EFFECTS. MUST BE ON USER LIST. INCREASE INCIDENCE OF MI
Term
WITH TZDS THE PATIENT IS EUGLYCEMIA. WHAT TYPE OF RISK FOR HYPOGLYCEMIA ARE THERE?
Definition
LITTLE RISK
Term
WHAT ARE 4 SIDE EFFECTS OF TZDS?
Definition
WEIGHT GAIN, CHF/EDEMA (OFTEN GIVEN WITH DIURETIC), INCREASED BONE FRACTURES, AND MI
Term
WHAT OTHER MEDICATION DO WE TYPICALLY GIVE WITH TZDS?
Definition
A DIURETIC
Term
WHAT 4 THINGS DOES GLUCAGON-LIKE PEPTIDE-1 (GLP-1) DO?
Definition
INCREASES INSULIN SECRETION, DECREASES GLUCAGON SECRETION, INCREASES UPTAKE OF GLUCOSE BY MUSCLES AND ADIPOSE TISSUE, INCREASES SATIETY (D/T AMYLIN).
Term
HOW DOES SYNTHETIC GLP-1/DPP-4 INHIBITORS WORK? GLP-1 IS RAPIDLY BROKEN DOWN BY WHAT ENZYME?
Definition
DIPEPTIDYL PEPTIDASE-4 (DPP-4). BY INHIBITING DPP-4, INCREASED GLP-1 HAS ANTIHYPERGLYCEMIA EFFECTS.
Term
NAME ARE 2 DRUGS THAT ARE A GLP-1 ANALOG?
Definition
EXENATIDE AND LIRAGLUTIDE (BOTH END IN TIDE)
Term
HOW IS EXENATIDE ADMINISTERED?
Definition
SQ
Term
HOW IS EXENATIDE MADE?
Definition
FROM THE SALIVA OF GILA MONSTER
Term
WHAT IS THE PEAK AND DURATION OF EXENATIDE?
Definition
PEAK IS 2 HRS AND DURATION IS 10 HRS
Term
WHAT ARE 3 SIDE EFFECTS ASSOCIATED WITH EXENATIDE?
Definition
NAUSEA, VOMITING, PANCREATITIS
Term
HOW IS LIRAGLUTIDE ADMINISTERED?
Definition
SQ
Term
NAME 2 DDP-4 INHIBITORS?
Definition
SITAGLIPTIN AND SAXAGLIPTIN
Term
WHAT IS A DRUG THAT IS A AMYLIN ANALOG?
Definition
PRAMLINTIDE
Term
WHAT IS THE PEAK AND DURATION OF PRAMLINTIDE?
Definition
20 MINUTES AND 2 HRS
Term
WHAT ARE 2 SIDE EFFECTS OF AMYLIN ANALOG?
Definition
HYPOGLYCEMIA AND GI UPSET (B/C AMYLIN HAS GI ACTIONS)
Term
WHAT 2 CLASSIFICATIONS OF ANTIDIABETICS CAUSE MORE PRONOUNCED HYPOGLYCEMIA?
Definition
SULFONYLUREAS AND AMYLIN ANALOGS
Term
HOW DOES SULFONYLUREAS INCREASE INSULIN SECRETION?
Definition
BY CAUSING CELLULAR DEPOLARIZATION
Term
TZDS INCREASE INSULIN SENSITIVITY THROUGH WHAT?
Definition
PPAR (GAMMA)
Term
WHAT DOES GLP-1 DO TO INSULIN?
Definition
INCREASE INSULIN SECRETION
Term
WHAT BREAKS DOWN GLP-1? WHAT HAPPENS IF YOU INHIBIT THAT ENZYME?
Definition
DPP-4 BREAKS DOWN GLP-1. INHIBITING DPP-4 = MORE GLP-1 TO INCREASE INSULIN
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