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Anticoagulants
Part 6
24
Nursing
Graduate
11/11/2014

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Cards

Term
FONDAAPARINUX (ARIXTRA) AND RIVAROXABAN (XARELTO) ARE SELECTIVE FOR WHAT?
Definition
Xa WITH ALMOST NO EFFECT ON THROMBIN (NOT AS DIFFUSE OF AN ACTION; THROMBIN ACTIVATES ALOT OF THINGS, Xa STARTS COMMON PATHWAY)
Term
FONDAPARINUX AND RIVAROXABAN MAY BE REVERSIBLE WITH WHAT? IS THERE AN ANTIDOTE?
Definition
FACTOR CONCENTRATES, NO OFFICIAL ANTIDOTE
Term
WHAT IS XARELTO ON AVAILABLE IN?
Definition
PO FORM
Term
DIRECT THROMBIN INHIBITORS INLIKE HEPARIN DO OR DON'T ACT THROUGH ANTITHROMBIN?
Definition
DONT
Term
DIRECT THROMBIN INHIBITORS ARE USEFUL IN PTS WITH WHAT DISEASE? WHAT LAB SHOULD BE MONITORED?
Definition
HIT, APTT
Term
THE MEDICATIONS HIRUDIN, DESIRUDIN, LEPIRUDIN, AND BIVALIRUDIN ARE DERIVED FROM WHAT? HOW ARE THEY CLEARED?
Definition
LEECH SALIVA. RENALLY
Term
HIRUDIN, DESIRUDIN, LEPIRUDIN, AND BIVALIRUDIN SHOULD BE STOPPED HOW LONG BEFORE SURGERY?
Definition
SHOULD BE STOPPED 8 HRS BEFORE SURGERY, WITH THE EXCEPTION, OF BIVALIRUDIN, WHICH HAS A SHORT HALF LIFE AND CAN BE STOPPED 3 HRS PRIOR TO SURGERY.
Term
WHAT TYPE OF HALF LIFE DOES ARGATROBAN HAVE?
Definition
SHORT HALF LIFE
Term
WHEN IS ARGATROBAN PROLONGED? WHAT TYPE OF EXCRETION DOES IT HAVE?
Definition
NOT AFFECTED BY RENAL DISEASE, BUT PROLONGED WITH HEPATIC DISEASE. BILIARY EXCRETION.
Term
WHAT DOES ARGATROBAN PROMOTE THE RELEASE OF TO INCREASE PERFUSION?
Definition
NITRIC OXIDE
Term
WHEN SHOULD ARGATROBAN BE DISCONTINUED BEFORE SURGERY?
Definition
4-6 HRS PRIOR TO SURGERY
Term
HOW IS DABIGATRAN (PRADAXA) ADMINISTERED?
Definition
ORALLY
Term
WHAT ARE 2 BENIFITS OF PRADAXA OVER COUMADIN?
Definition
NO MONITORING NECESSARY AND NO DIETARY RESTRICTIONS
Term
WHEN SHOULD DABIGATRAN (PRADAXA) BE DISCONTINUED PRIOR TO SURGERY?
Definition
5 DAYS PRIOR TO SURGERY
Term
HOW DOES THROMBOLYTICS/FIBRINOLYTICS WORK?
Definition
PLASMINOGEN ACTIVATORS CONVERT PLASMINOGEN TO PLASMIN, WHICH BREAKS DOWN FIBRIN INTO FIBRIN SPLT PRODUCTS
Term
WHAT TYPE OF CLOTS IS THROMBOLYTICS/FIBRONOLYTICS MORE EFFECTIVE AT DISSOLVING?
Definition
NEW CLOTS VS OLDER, TIGHLY BOUND CLOTS
Term
WHAT ARE THE HALF LIVES OF ALL THROMBOLYTICS/FIBRINOLYTICS?
Definition
5-23 MINUTES
Term
WHAT ARE THE 2 MAIN SIDE EFFECTS WITH THROMBOLYTICS/FIBRINOLYTICS?
Definition
BLEEDING (ESPECIALLY INTRACRANIAL) AND HYPOTENSION (NOT NECESSARY BECAUSE OF BLEEDING)
Term
STREPTOKINASE IS A PROTEIN PRODUCED BY WHAT?
Definition
B-HEMOLYTIC STREP. ANTIGEN DEVELOPMENT AND ALLERGIC REACTION ARE MORE COMMON THAN WITH OTHER FIBRINOLYTICS.
Term
STREPTOKINASE MAY RESULT IN WHAT?
Definition
SYSTEMIC FIBRINOLYSIS
Term
WHAT IS A MAIN CONCERN FOR TISSUE PLASMINOGEN ACTIVATOR (TPA) ALTEPLASE
Definition
FIBRIN-SPECICIF, BUT SYSTEMIC BLEEDING IS STILL A CONCERN. MUCH MORE EXPENSIVE THEN STREPTOKINASE BUT MUCH MORE EFFECTIVE
Term
TENECTEPLASE (TNKASE) AND RETEPLASE (RETEVASE)ARE UNIQUE HOW?
Definition
THEY ARE GENETICALY ENGINEERED TPA TO INCREASE FIBRIN SPECIFICITY.
Term
REVERSAL OF FIBRONOLYTICS/THROMBOLYTICS IS THROUGH WHAT?
Definition
ANTIFIBRINOLYTIC DRUGS
Term
WHEN SHOULD THROMBOLYTICS/FIBRINOLYTICS BE DISCONTINUED PRIOR TO SURGERY?
Definition
1-3 HRS
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