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Details

Anticoagulant & Thrombolytic Doses
CVT
16
Pharmacology
Professional
08/31/2012

Additional Pharmacology Flashcards

 


 

Cards

Term
Sodium heparin
Definition
• 50 u/kg
• For acute myocardial infarction (AMI) 5000u loading and 1000 u/hr
Term
ReoPro (Abciximab)
Definition
• .25 mg/kg bolus
• Then .125 mcg/kg/min for MI
• For PCI post, 10 mcg/kg/min for 12 hours
Term
Tirofiban HCl (Aggrastat)
Definition
• Initial dose of 0.4 mcg/kg/min for 30 minutes
• Followed by 0.1 mcg/kg/min for 48 to 108 hours or 12 – 24 hours after coronary intervention
Term
Bivalirudin (Angiomax)
Definition
• Initially, 1 mg/kg IV bolus just before PCI
• Infusion at 2.5 mg/kg/hr for 4 hours
• Administer another IV infusion at 0.2 mg/kg/hr for up to 30 hours as needed
• Store prepared solution for up to 24 hours at 36 to 46 degrees Fahrenheit
• Give with 325 mg of aspirin
Term
Argatroban (Acova)
Definition
• Begin infusion of 25 mcg/kg/min and administer bolus dose of 350 mcg/kg (over 3 to 5 minutes)
• ACT should be checked 5 to 10 minutes after bolus
• Proceed with procedure if ACT is > 300 seconds
Term
Integrilin (Eptifibatide)
Definition
• For MI 180 mcg/kg bolus then 2 mcg/kg/min for 72 hours
• For PCI 135 mcg/kg bolus then .5 mcg/kg/min
Term
Lovenox (Enoxaparin)
Definition
• 1 mg/kg BID with ASA for 2 - 8 days
Term
Protamine sulfate
Definition
• 1 mg neutralizes 100 units of heparin
• 50 mg max in a 10 minute period
Term
Activase (tPA)
Definition
• Loading 6 - 10 mg over 1 - 2 min
• 60 mg over the first hour
• Second and third hours 20 mg each
• Weight < 65 kg give 1.25 mg/kg over three hours
Term
Retavase
Definition
• 10 units over 2 min
• Repeat 10 unit in thirty minutes
Term
Ergonovine
Definition
1ml, 2ml, 5ml, given 3 - 5 min apart
Term
Captopril
Definition
• 6.25 mg to 25 mg TID
• Advance to 25 mg TID
• Not to exceed 450 mg/day
Term
Sodium Bicarbonate
Definition
1 mEq/kg every 10 minutes
Term
Aspirin
Definition
• Analgesic/antipyretic: 325 - 650 mg PO q 4 hours as needed
• Acute MI: 325 mg (or 4 x 81 mg chewable tablets to facilitate sublingual absorption and to expedite antiplatelet activity)
• Thromboembolic disorders: 325 - 650 mg PO QD or BID
• MI prophylaxis: 81 - 325 mg PO QD
Term
Clopidogrel (Plavix)
Definition
• 75 mg PO QD is recommended
• For ACS with or without PCI, load with 300 mg and then continue with 75 mg daily
Term
Enalapril (Vasotec)
Definition
Hypertension
• PO: 5 mg/day; may increase to 10 to 40 mg/day in 1-2 divided doses
• IV: 1.25 mg slow IV push over 5 minutes every 6 hours; may give up to 5 mg every 6 hours in hypertensive emergencies
• CHF: 2.5 mg PO QD or BID; may increase up to 5 to 20 mg/day in 1 to 2 divided doses (max of 40 mg/day
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