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Anticholinesterase Compounds
Anti.. compounds
8
Biology
Undergraduate 1
10/13/2010

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Term
Name a plant compound which exhibits Anticholinesterase activity. G and S.
Definition
Physostigmine, Physostigma venenosum
Term
Synthetic compounds with this activity include:
Definition
Insecticides and Nerve Poisons
Term
Physostigmine Mechanism:
Definition
- Inhibitor of acetylcholinesterase resulting in increased acetylcholine in synapses and stimulation of
- postganglionic muscarinic nerve receptors
- postganglionic cholinergic sweat gland receptors
- ganglionic receptors
- skeletal muscle nerve receptors
Term
Physiological cholinergic effects in autonomic nervous system: (3)
Definition
- diaphoresis (intense sweating)
- reduced heart rate
- smooth muscle stimulation in intestines and bladder
Term
physostigmine:
Genus and species:
common names:
geography:
Origin:
Ethnomedical issues
Definition
Physostigma venenosum in Fabaceae
CN: calabar, ordeal, esere bean
Geo:rainforest of west Africa
Origin: Efik peopl eof the Calabar region of south-eastern Nigeria
Ethnomedical uses: Dry beans as ordeal poison in trials for witchcraft. carried for protectin against witchcraft.
Term
Physostigmine:
Treats (2):
Neostigmine, pyridostigmine, demercarium are used as/to?
edrophonium:
Definition
treats: glaucoma, and is antidote for anticholinergic poisoning
NP and D: intestinal stimulant, treatment of myasthenia gravis
E: used to diagnose and treat myasthenia gravis
Term
Physostigmine (eserine)
chemical class:
Derivatives:
Physostigmine --->
Definition
chem: alkaloid
Physostigmine ---> neostigmine
Term
Neostigmine --->
Definition
neostigmine ----> edrophonium
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