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Antiarrhythmic Drugs
Part 2
23
Nursing
Graduate
11/01/2014

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Term
WHAT DRUGS WORK ON CLASS 1 ANTIARRHYTHMICS?
Definition
NA CHANNEL BLOCKERS (OPEN DURING UPSTROKE, INACTIVE DURING PLATEAU, CLOSED FOR REPOLARIZATION).
Term
HOW DO SODIUM CHANNEL BLOCKERS WORK?
Definition
BIND TO SODIUM CHANNELS IN THE OPEN OR INACTIVATED STATE, THEN DISSOCIATE DURING THE RESTING (CLOSED) STATE.
Term
WHAT IS USE-DEPENDENT BLOCKADE?
Definition
FREQUENCY OF USE INCREASES TIME SPENT IN OPEN OR INACTIVE STATE; DECREASES THE RESTING TIME.
Term
FOR SODIUM CHANNEL BLOCKERS WHAT RESULTS WITH TACHYCARDIA?
Definition
INCREASE IN OPEN CHANNELS AND INCREASE USE OF NA CHANNELS.
Term
IN THE SA NODE, CLASS 1 ANTIARRHYTHMICS DECREASE THE RATE OF FIRING BY WHAT 2 MECHANISMS?
Definition
INCREASES THRESHOLD AND DECREASES THE SLOPE OF PHASE 4. THESE ARE SAME AS PNS EFFECTS!!!
Term
HOW MANY CLASSES OF 1 DRUGS ARE THERE?
Definition
3. 1A,1B, AND 1C.
Term
WHICH CLASS HAS THE GREATER AFFINITY FOR OPEN STATE OF SODIUM CHANNEL AND RESULTS IN SLOW RECOVERY?
Definition
CLASS 1A.
Term
CLASS 1A ALSO BLOCKS WHAT?
Definition
POTASSIUM CHANNELS.
Term
IN THE VENTRICULAR MYOCYTE WHAT DOES CLASS 1A DRUGS DO?
Definition
SLOWS THE RATE OF PHASE 0 DEPOLARIZATION (SLOWED DEPOLARIZATION) AND SLOWS THE RATE OF PHASE 3 REPOLARIZATION (PROLONGED ACTION POTENTIAL AND REFRACTORY PERIOD).
Term
WHAT ARE 2 EKG EFFECTS OF CLASS 1A DRUGS?
Definition
PROLONGED QRS AND PROLONGED QT-INTERVAL.
Term
WHAT ARE THE 3 DRUGS FOR CLASS 1A?
Definition
QUINIDINE, PROCAINAMIDE, ANDDISOPYRAMIDE.
Term
WHICH DRUG IS QUINIDINE SIMILAR TO AND HOW DOES IT WORK?
Definition
ATROPINE. IS EXERTS AN ANTICHOLINERGIC EFFECT WHICH CAN INCREASE CONDUCTION VELOCITY THROUGH SA AND AV NODE.
Term
THE USE OF QUINIDINE IS UNCOMMON DO TO 2 MAIN SIDE EFFECTS. WHAT ARE THEY?
Definition
GI UPSET AND HEADACHE.
Term
HOW IS QUINIDINE METABOLIZED?
Definition
BY CYP450 ENZYMES
Term
WHAT ARRYTHMIA CAN QUINIDINE INCREASE THE RISK OF?
Definition
TORSADES DE POINTES
Term
WHAT KIND OF LEVELS CAN QUINIDINE INCREASE?
Definition
DIG LEVELS AMIODARINE AND VERAPAMIL ALSO WORK THIS WAY.
Term
PROCAINAMIDE IS A DERIVATIVE OF WHAT?
Definition
THE LA PROCAINE
Term
HOW IS PROCAINAMIDE METABOLIZED?
Definition
BY THE LIVER TO AN ACTIVE METABOLITE
Term
WHAT DOES LONG TERM USE CAUSES?
Definition
LUPUS-LIKE SYNDROME
Term
WHAT KIND OF ANTICHOLINERGIC EFFECTS DOES PROCAINAMIDE HAVE AND DOES IS ALTER DIG LEVELS?
Definition
FEW ANTICHOLINERGIC EFFECTS AND DOES NOT ALTER DIG LEVELS.
Term
WHAT IS UNIQUE ABOUT DISOPYRAMIDE?
Definition
IT HAS MORE ANTICHOLINERGIC (BLOCKS PNS) EFFECTS THAN QUINIDINE. SE IS ATROPINE LIKE EFFECTS.
Term
WHAT CAN DISOPYRAMIDE DO TO CONTRACTILITY AND HEART FAILURE?
Definition
DECREASE CONTRACTILITY AND CAN CAUSE HF.
Term
WHAT IS DISOPYRAMIDE USED ONLY FOR?
Definition
VENTRICULAR ARRHYTHMIAS.
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