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Anti-Parkinsons
Module 3.5
13
Pharmacology
Graduate
11/19/2011

Additional Pharmacology Flashcards

 


 

Cards

Term
Dopamine
Definition
NT focused on with Parkinson's
Term
D1 receptor
Definition
stimulation is excitatory for secondary messengar systems
Term
D2 receptors
Definition
stimulation causes inhibition of second messengar systems
Term
Parkinson's pathophysiology
Definition

-Direct pathway (movement- enabling) is understimulated 

 

-Underinhibition of indirect pathway (movement-inhibiting)

 

First sx- 70% neurons destroyed

Autopsy-95% neurons destroyed

Sx of disease: bradykinesia, rigidity, impaired postural balance, tremor

Term
Parkinson's pharm
Definition

only treats sx

incerases dopamine activity in brain

Term
Levodopa
Definition

Class: Dopamine precursor

Clinical app: use another class first, and then add this on

 

MAE: precursor so is readily transported across BBB (dopamine cant)

 

A/E: nausea due to conversion in GI, tolerance and desensitization, dyskinesia

 

PK:1-3% reaches CNS when alone,administered with carbidopa, does not cross BBB so levodopa can be converted after crossing BBB

 

Dosing: requires higher doses as pt has been on longer

Term
Parlodel (ergot deriv), Mirapex, Requip
Definition

Class:Dopamine Receptor Agonists

 

MOA:Directly target postsynaptic DA receptors

 

pk:no enzymatic conversion required, longer half-life than levodopa (less blood level fluctuations)

 

A/e: sedation vivid dreams, hallucinations

Term

 

Selegiline, rasalagine

Definition

Inhibitors of dopamine and/or L-DOPA metabolism

 

- MAOB inhibitors

-doesn't interfere with MAO-A metab

Metabolite is amphetamine- POSSIBLY TOXIC

Term
 entacopone
Definition

COMT inhibitors (enzyme that breaks down dopa)

 

Entacapone works peripherally only

increase levels of levodopa

 

Term
Tolcapone
Definition

COMT inhibitors (enzyme that breaks down dopa)

A/e: Hepatotoxicity

Term
Symmetrel
Definition

Class: Non-dopaminergic agents

MAE: unknown

Clinical use: treatment of levodopa induced dyskinesias

Term
Artane, Cogentin
Definition

Class: non-dopa agent

 

Use: Reduction of tremor

 

receptor: muscarnic receptor antagonist

 

A/E:ANTICHOLINERGIC

Term
summary of drugs
Definition
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