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Anti-inflammatory drugs
anti inflammatory drugs
26
Medical
Professional
01/04/2008

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Cards

Term

Alprostadil

Definition
  • PGE1 (prostaglandin)
  • temporarily maintains Patent ductus arteriosis
Term

Indomethicin

Definition
  • Cyclooxygenase inhibitor, inhibits prostaglandin synthesis
  • Closes Patent ductus arteriosis
Term
Misoprostal
Definition
  • prostaglandin analog
  • oral tx for gastric ulcers
  • side effects: abdominal discomfort, diarrhea
Term

Dinoprostone and carboprosttromethamine

Definition
  • PGE2, PGF2a
  • contract uterus
Term
Carboprost(15 methyl PGF2a)
Definition
  • intramuscularly, it can be used instead of oxytocin to reduce postpartum hemorrhage
Term
Aspirin
Definition
  • analgesic, antipyretic, anti-inflammatory, anti-platelet, Classic NSAID
  • completely absorbed from stomach and intestine in unionized form
  • Irreversibly inhibits prostaglandin biosynthesis by acetylating COX
Term
Acetaminophen
Definition
  • weak base
  • analgesic, antipyretic, NOT anti-inflammatory or anti platelet
  • Side effect: Severe hepatotoxicity, N-acetylcysteine prevents this
Term
Celecoxib (Celebrex)
Definition
  • COX-2 inhibitor, sulfonamide
  • significant first pass metabolism
  • COX2 inhibitors reduce production of prostacyclin, an antithrombotic
Term
Glucocorticoids
Definition
  • Enters cell membrane, goes to GRE pro, increase steroid responsive tgt genes, decrease cytokines, NK
  • Side effects: adrenal atrophy, hypertension, GI bleeding, immunosuppression, fetal growth retardation, cataracts and glaucoma
Term

Zileuton

Definition
  • inhibits 5-lipoxygenase, (leukotriene modifier)
  • inhibits CYP3A4--influences metab of terfenadine, warfarine and theophylline
  • Tx for mild to mod athsma, alternative to inhaled corticosteroids
Term

Zarfirlukast and Montelukast

Definition
  • Leukotriene receptor antagonist
  • Inhibits CYP3A4/CYP2C9: increase warfarin 1/2 life
  • Tx for mild to moderate athsma, alternative to inhaled corticosteroids
Term

Hydroxychloroquinone

Definition
  • Anti malarial agent, Disease modifying Antirheumatic drug (DMARD)
  • Tx for rheumatoid arthritis
Term
Penicillamine
Definition
  • Chelating agent, DMARD
  • Tx for RA
Term
Infliximab
Definition
  • Immunosuppressive, DMARD
  • Tx for RA
  • Prevent proliferation of B and T cells
  • Inhibits TNF-a function
  • Co-administer with methotrexate to reduce development of Ab to drugs; long term tx
Term
Etanercept
Definition
  • Inhibits TNF-a function, cytokine blocker
  • Tx for RA
Term
Anakinra
Definition
  • Inhibits IL-1 function
  • Tx for RA
Term
Abatacept
Definition
  • Inhibits T cell activation by mimicking CD28 and preventing CD28 from binding CD80 via costimulatory pathway
  • approved tx for RA patients who don't respond to anti TNF-a tx
  • Side effects: can't use DMARD with abatacept, frequent infections
Term
Rituximab
Definition
  • Inhibits B cell function
  • tx for RA when anti TNFa fails, and non hodgkins lymphoma
  • Side effect: Fatal infusion reaction within 24 hours of infusion
Term
Chlorpheniramine
Definition
  • aka Triaminic
  • short duration (3-6 hr), cause sedation, anti-nausea, anti motion sickness
  • 1st gen H1 Receptor antagonist
Term
Diphenhydramine
Definition
  • Aka Benadryl
  • short duration (3-6 hr), causes sedation
  • 1st generation HI Receptor antagonist
  • anti nausea, anti motion sick
  • anticholinergic, anti a-adrenergic, antiserotonergic effects
Term
Fenofexadine
Definition
  • 2nd gen H1 Receptor antagonist
  • Don't penetrage CNS, therefore no sedation
  • not useful for antinausea, not anticholinergic, a-andronergic or serotonergic
  • long duration (12-24 hr)
Term
Cetinzine
Definition
  • Aka Zyrtec
  • 2nd gen H1 Receptor antagonist
  • no anticholinergic, anti a adrenergic or anti serotonergic, no sedation, no antinausea
  • Long duration (12-24 hr)
  • Doesn't penetrate CNS
Term
Sumatriptan
Definition
  • Serotonin agonist
  • don't administer with SSRI--restlessness, hallucinations, loss of coord, tachycardia, rapid bp, increased body temp
Term
Cimetidine
Definition
  • potent inhibitor of P450 metabolism
  • H2 receptor antagonists
  • reduces NSAID induced dyspepsia, esophageal reflux
Term
Ondansetron
Definition
  • Seratonin Antagonist
  • Ser5ht3, antagonish for nausea and vomiting
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