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Anti-arrythmic agents
Physio and Agents of Arrythmias
14
Pharmacology
Graduate
11/14/2010

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Cards

Term
P wave
Definition
depolarization of R and L atria
Term
QRS complex
Definition
depolarization of R and L ventricles
Term
T wave
Definition
re-polarization of R and L ventricles
Term
Vaughn williams classification
Definition
Class I: Na channel blockers

Class II: beta blockers

Class III: K channel blockers

Class IV: Ca channel blockers
Term
Class I-A
Definition
Quinidine, procainamide, and disopyramide
Term
Quinidine: cardiac effects
Definition
Automaticity:
-depresses SA node and etopic pacemakers

Conduction:
-direct effect slows conduction through atr. vent. and punk fib
-indirect effect increase AV conductio

ERP:
-prolongs ERP at atri. vent. purk fibs
Term
Quinidine: toxicity
Definition
-GI irritation
-cinchonism
-cardio toxicity
**can cause V fib.**
Term
Quinidine: Tx
Definition
Supra-ventricular arrythmias
-atrial flutter, A fib.
Ventricular arryhtmias
vent. tachycardia
durg induced arrythmia
Term
Class I-B
Definition
lidocaine
phenytoin
tocainide
mexiletine
Term
Lidocaine
Definition
emergency mang. of arrythmias

NTI

IV therapy for ventricular arrythmias

preferential effect on ischemic tissue

slow depolarization of cardiac tissue
Term
Class I-C
Definition
encainide
flecainide
Term
Class I-C agents
Definition
-potent anti-arrythmic drugs
-decreases automaticity
-decreases elect impulse through av node and ventricles
-partic effectiveness in suppressing premature ventricular contractions
Term
Class III
Definition
Bretylium
Amiodarone
Term
Class III agents
Definition
-acute Tx of life-threatening arrythmias (V fib recurrent v. tachycardia)
-prolong cardiac repolarization
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