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ANS antagonist
ANS Antagonists
11
Pharmacology
Pre-School
10/31/2011

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Term
*Phenoxybenzamine *Phentolamine
Definition
Nonselective alpha antagonist *Phenoxybenzamine- used for pheocromocytoma, otherwise can get large reflex tachycardia
Term
Doxazosin *Prazosin Alfuzosin *Tamsulosin Terazosin Yohimbine
Definition
α1 selective antagonist (caution: arrythmias- sudden death) Use: hypertension treatment, CHF, low tachycardia SE: syncope *Prazosin (and Afusozin)- BPH (blocks a1A receptor)- SE: syncope 1st admin and inc dosages *Tamsulosin- a1-D spec, urinary tract-->micturition, less orth hypo then other "-zosin" drugs -Favorable effect: INC HDL/LDL ratio (lowers serum lipids)- so lowers cholesterol without lowering HDL :)
Term
*Propranolol, Pindolol
Definition
Nonselective beta antagonist *Propranolol- low dose for performance anxiety *Pindolol- good for hypertensive patients with bradycardia or exercise intolerance
Term
*Labetalol
Definition
Nonselective ß, α1 blocker (antagonist) **potent anti-hypertensive, CAN be used during EMERGENCIES
Term
Acebutolol, Metoprolol, *Atenolol, Bisoprolol, Esmolol
Definition
*ß1 (cardio-) selective antagonist
Term
Tubocurarine, Atracurium, Mivacurium, Vecuronium
Definition
Competitive NMJ blocker
Term
Succinylcholine
Definition
Depolarizing NMJ blocker
Term
Baclofen
Dantrolene
Tizanidine
Definition
Skeletal Muscle Relaxant
Term
Nicotine
Definition
Nicotinic Agent
Term
Varenicline
Definition
Nicotinic Agent
Term
beta blockers in general
Definition
MOA: DEC Renin, DEC CO
SE
* withdrawl syndrome: rebound tachycardia
-airway toxicity (bronchoconstriction)
-Augments hypoglycemia in insulin dep patients- masks the tachycardia associated with hypoglycemia
-INC TG and LDL, DEC HDL
-NSAIDS may block HT effects
use other HT drugs first unless patient has heart issues then use beta blocker
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