Shared Flashcard Set

Details

Anginal Treatments
N/A
6
Medical
Graduate
10/04/2011

Additional Medical Flashcards

 


 

Cards

Term
Nitric Oxide
Definition
Activates guanylyl cyclase, leading to an increase in cGMP, which facilitates dephosphorylation of myosin light chains, causing smooth muscle relaxation and vasodilation.
Take breaks from NO at night to prevent tolerance development.
Nitroglycerin is converted to NO inside smooth muscle cell.
Primary effect is venodilation, leading to decreased preload. May also cause orthostatic hypotension and syncope.
Term
Calcium Channel Blockers
Definition
Block L-type Calcium channels, preventing activation of calmodulin, preventing activation of myosin light chain kinase, preventing phosphorylation of myosin light chains.
Decreases peripheral resistance and reduces coronary vasospasm.
Term
Dihydropyridines
Definition
Ca channel blockers with greater smooth muscle effects than cardiac effects.
Term
Nondihydropyridine Ca channel Blockers
(Verapamil, Diltiazem)
Definition
More cardiac action than dihyd. Ca blockers. Cause less reflex tachycardia.
Term
pFOX Inhibitors
Definition
Inhibit fatty acid oxidation pathway in myocardium, shifting metabolism toward glucose usage, which requires less oxygen consumption.
Term
Ranolazine
Definition
Originally thought to be a pFOX inhibitor. Now believed to reduce contractility by blockade of late Na current, leading to decreased intracellular Ca.
Supporting users have an ad free experience!