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Anestetics II
Gases/Vapors/MAC
10
Medical
Professional
04/01/2013

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Cards

Term
Boiling Point definition
Definition
Temperature at which vapor pressure exceeds atmospheric pressure at equillibrium
Term
Increasing BP
Definition
NO
Term
Solubility
Definition
Low: Des/Sevo
Med: iso
High: Halothane
Term
increase speed onset
Definition
decrease solubility
increase concentration inspired
increase ventilation rate

(think baby crying goes down faster)
Term
MAC's
Definition
MORE POTENT:
Halo = .75
iso = 1.17
sevo = 1.8
des = 6.0
NO2 = 104
LESS POTENT

Mac aware = .4 MAC
mac awake = .25
BAR = 1.5 * MAC

MAC;s are additive
Term
NO
Definition
low potency (high mac) with rapid induction /termination

prolonged use may cause megloblastic anemia via methionine syntase
Term
Desflurane
Definition
low potency (mac = 6.0)
rapid onset with low fat solubility
high vapor pressure

immune mediated hepatotoxicity poss.
PUNGENT ODOR
Term
Sevoflurane
Definition
moderate potency (mac = 1.7)

low blood solubility = fast onset
SWEET smelling = good mask inducer!

prolonged use = biotransformation to compound A = kidney damage

some heat producting reactions
Term
isoflurane
Definition
high potency MAC = 1.17
intermediate solubility
VERY STABLE (long shelf life)
smells horrible
Term
Halothane
Definition
High potency high solubility sweet smelling anestetic with high risk immune mediated hepatotoxicity

sensitizes heart to catecholamines (vtac/afib)
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