Shared Flashcard Set

Details

Alcohols
Pharmacology
21
Medical
Professional
02/06/2012

Additional Medical Flashcards

 


 

Cards

Term
rate limiting step of OH synthesis/cofactor?

What does it produce?
Definition
alcohol dehydrogenase ADH

NAD

Acetaldehyde and NADH
Term
secondary metabolism orgnas
Definition
lungs and kidneys
Term
what is the Mellanby Effect?
Definition
impairment is greater at a given blood alcohol level when BAC is increasing than for the same BAC when the blood alcohol level is falling
Term
GABA receptors when OH is present
Definition
enhanced capacity to bind
Term
NMDA effects w/OH
Definition
inhibition
Term
when do symptoms of OH w/d appear?
Definition
12-72 last drink
peak effects 24-48 hrs
recovery 5-7 days
Term
DOC for OH w/d
Definition
chlorodiazepoxide or diazepam
Term
effect of OH on heart
Definition
low to moderate doses: vasodilation/hypothermia
Term
effect of OH on GI/liver tract
Definition
fatty degeneration--cirrhosis- portal HTN

erosive gastritis
Term
endocrine effects of OH
Definition
gynecomastia and testicular atrophy
Term
how to treat acute OH ethanol intoxication
Definition
supportive care

look out for diabetic coma
Term
primary features of fetal alcohol syndrome
Definition
microcephaly, prenatal growth deficiency, and short palpebral fissures
Term
mech of action for Disulfiram
Definition
inhibits ALDH

leading to accumulation of Acetaldehyde
Term
what is acetaldehyde syndrome
Definition
vasodilation
severe headache
chest pain
blurred vision
nausea
Term
mech of action for Naltrexone
Definition
blocking of central reward pathways

**less side effects than disulfriam**
Term
methanol poisoning
Definition
muscle weakness
euphoria
suppression of inhibitions
induce retinal damage
Term
this should be looked for in methanol poisoning
Definition
metabolic acidosis w/anion gap

fixed dilated pupils
retinal damage
Term
DOC to treat methanol poisoning
Definition
fomepizole
Term
mech of action for fomepizole
Definition
competitive inibitor of alcohol dehydrogenase
Term
what are the metabolic products of methanol
Definition
formaldehyde and formic acid
Term
caffeine on etOH intake
Definition
blunt an individual's perception of ethanol impairment
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