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Alabama NUR 326 Pharm Test 1
University of Alabama Nursing, 326 Pharmacology
70
Medical
Undergraduate 3
09/02/2007

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Term
Pharmacology
Definition
The study of the interaction of chemicals with living organisms to produce biological effects.
Term
Affinity
Definition
ability to chemically connect
Term
Food, Drug, and Cosmetic Act of 1938
Definition
Regulate the manufacture, distribution, advertising, and labeling of drugs.

Required proof of saftey before a durge could be marketed.
Authorized factory inspections.
Started penalties for fraudulent claims and misleading labels.
Term
Comprehensive Druge Abuse Prevention and Control Act of 1970
Definition
Regulated distribution of narcotics and other drugs of abuse

Categorized these drugs according to therapeutic usefulness and potential for abuse.

Named things "controlled substances" and we must now account for meds in the hospital.
Term
Drug Regulation Reform Act of 1978
Definition
Shortened time to get drugs developed
Term
Orphan Drug Act of 1983
Definition
Pays companies to make meds for disease with lower disease rates
Term
Drug Enforcement Administration
(DEA)
Definition
enforces the controlled substances
Term
Conditions that must be met for a nurse to give a drug:
Definition
Valid Order
Presceiber and nurse must be licensed
RN must KNOW about the drug
Use correct technique and precautions when administering each medication
Term
Schedule 1 Drugs
Definition
Drugs that are not approved for medical use and have high abuse potentials
Term
Schedule 2 Drugs
Definition
Drugs that are used medically and have high abuse potentials
Term
Schedule 3 Drugs
Definition
Drugs with less potential for abuse
Term
Schedule 4 Drugs
Definition
Drugs with some potential for abuse
Term
Schedule 5 Drugs
Definition
Products containing moderate amounts of controlled substances
Term
Pharmacokinetics
Definition
Involves drug movement through the body to reach sites of action, metabolism, and excretion
Term
Three Main Pathways for Drug Movement Across Cell Membranes
Definition
Direct Penetration, Protein Channels, Carrier Proteins
Term
Distribution
Definition
The transport of drug molecules within the body
Term
Metabolism
Definition
The method by which drugs are inactivated or biotransformed by the body
Term
Excretion
Definition
elimination of a drug from the body
Term
Narrow Theraputic Window
Definition
Very small amounts given. *Death by decimal*
Term
Pharmacodynamics
Definition
Involves drug actions on target cells and the resulting alterations in cellular biochemical reactions and functions ("what the drug does to the body")
Term
Agonist
Definition
Drugs that produce effects similar to those produced by naturally occurring hormones
Term
Antagonists
Definition
Drugs that inhibit cell function by occupying receptor sites
Term
Additive Effects
Definition
Occur when two drugs with similar pharmacologic actions are taken: A+B=AB
Term
Synergism
Definition
Two drugs with different sites of action produce greater effects when taken together: A+B=AB2
Term
Interference
Definition
One drug with the metabolism or elimination of a second drug may result in intensified effects of the second drug
Term
Displacement
Definition
Displacement of one drug from plasma protein-binding sites by a second drug increases the effects of the displaced drug
Term
Adverse Effect
Definition
life threatening
Term
Side Effect
Definition
annoying
Term
Individualization
Definition
Drugs affect people differently
Term
Quality Tested
Definition
Tested by the FDA; not herbs, etc.
Term
Drug Fever
Definition
Fever associated with administration of a medication
Term
Idiosyncrasy
Definition
An unexpected reaction to a drug that occurs the first time it is given
Term
Drug Dependence
Definition
it takes more of a substance for it to work
Term
Carcinogenicity
Definition
The ability of a substance to cause cancer
Term
Teratogenicity
Definition
The ability of a substance to cause fetal defects
Term
Acetylation
Definition
The liver trying to get rid of things.
Term
Five "Rights"
Definition
Right drug, dose, client, route, time
Term
ADME of Pharmacokinetics
Definition
Absorption, Distribution, Metabolism, Excretion
Term
Subcutaneous Injection
Definition
In the fat
Term
Intramuscular Injection
Definition
In the muscle
Term
Intravenous Injection
Definition
In the veins; quickest route
Term
Intrathecal Injection
Definition
In the spinal chord
Term
3 Routes of Drug Elimination
Definition
In the feces, urine after metabolism, or urine without prior metabolism
Term
Broslow Tape
Definition
Tells what type of drugs and equiptment to use based on size of child
Term
How are pediatric doses measured?
Definition
Based on body surface area
Term
Should older adults be given higher or lower doses of meds?
Definition
Lower, because the drugs last longer and act stronger.
Term
Class A Drug
Definition
No risk demonstrated to fetus
Term
Class B Drug
Definition
No adverse effects in animals. No human studies available.
Term
Class C Drug
Definition
Only given when absolutely needed. Animal studies have shown adverse reactions. No human studies available.
Term
Class D Drug
Definition
Definite fetal risks. May still be given in life threatening conditions.
Term
Class X Drug
Definition
Absolute teratogen. Never used! (Accutane)
Term
Phase 1 Testing
Definition
Drugs tested on young males (18-30). No guarentee on what the outcome will be.
Term
Phase 2 Testing
Definition
Small group of people that have the disease are tested. The size of the group is directly proportional to the prevalance of the disease.
Term
Phase 3 Testing
Definition
It didn't kill the Phase 2 people, so it's tested more broadly.
Term
Phase 4 Reporting
Definition
Drug is prescribed, but side effects are reported to the FDA by doctors. (Vioox)
Term
Negligence
Definition
Failure to do something that could be expected of the reasonable, prudent nurse.
Term
Black Box Warnings
Definition
Black outlined drug warnings. Improtant warning information.
Term
How many times should you read a drug lable?
Definition
Three times
Term
Nomogram
Definition
Used to estimate the surface area of infants and young children (Broslow Tape)
Term
Nomogram
Definition
Used to estimate the surface area of infants and young children (Broslow Tape)
Term
Nomogram
Definition
Used to estimate the surface area of infants and young children (Broslow Tape)
Term
Prototypes
Definition
Individual drugs that represent groups of drugs
Term
Prototypes
Definition
Individual drugs that represent groups of drugs
Term
Blood-brain barrier
Definition
Capillaries with tight walls which limits the transport of medications in the Central Nervous System
Term
Vulnerable populations
Definition
Physiological Characteristics that lead to Pharmacokinetic consequences
Term
Generic Name
Definition
Related to the chemical or official name and is independent of the manufacturer (eg, amoxicillin)
Term
Trade Name
Definition
Designated and patented by the manufacturer
Term
Trade Name
Definition
Designated and patented by the manufacturer
Term
Serum Drug Level
Definition
Laboratory measurement of the amount of a drug in the blood at a particular time
Term
Efficacy
Definition
The ability of a compound to stimulate the receptor to some action; efficiency
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