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37
Medical
Graduate
02/09/2009

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Term
Disease caused by excess ergot alkaloids
Definition
St. Anthony's Fire
Term
Endogenous substances commonly interpreted as histamine, serotonin, prostaglandins, and vasoactive peptides
Definition
Autocoids
Term
Syndrome of hypersecretion of gastric acid and pepsin usually caused by gastrinoma; it is associated with severe peptic ucleration and diarrhea
Definition
Zollinger-Ellison Syndrome
Term
Drug that causes contraction of the uterus
Definition
Oxytocin
Term
Distribution of histamine receptors H1, H2, and H3
Definition
Smooth muscle; stomach, heart and mast cells; nerve endings, CNS respectively
Term
Prototype antagonist of H1 and H2 receptors
Definition
Diphenhydramine and ranitidine, respectively
Term
1st generation antihistamine that is highly sedating
Definition
Diphenhydramine
Term
1st generation antihistamine that is least sedating
Definition
Chlorpheniramine or cyclizine
Term
2nd generation antihistamines
Definition
Fexofenadine (Allegra), loratadine (Claritin), and cetirizine (Zyrtec)
Term
Generation of antihistamine that has the most CNS effects
Definition
First generation due to being more lipid-soluble
Term
Major indication for H1 receptor antagonist
Definition
Use in IgE mediated allergic reaction
Term
Antihistamine that can be used for anxiety and insomnia and is not addictive
Definition
hydroxyzine (Atarax)
Term
H1 antagonist used in motion sickness
Definition
Dimenhydrinate, meclizine, and other 1st generation
Term
Most common SE of 1st generation antihistamines
Definition
Sedation
Term
Lethal arrhythmias resulting from concurrent therapy with azole fungals (metabolized by CYP3A4) and there antihistamines which inhibit the 3A4 iso-enzyme
Definition
Terfenadine and astemizole (have been removed from market)
Term
H2 blocker that causes the most interactions with other drugs
Definition
Cimetidine
Term
Clinical use for H2 blockers
Definition
Acid reflux disorder, duodenal ucler and petic ulcer disease
Term
Receptors for serotonin (5HT-1) are located
Definition
Mostly in the brain, and they mediate synaptic inhibition via increased K+ conductance
Term
5HT-1d agonist used for migraine headaches
Definition
Sumatriptan, naratriptan, and rizatriptan
Term
Triptan available in parenteral and nasal formulations
Definition
Sumatriptan
Term
H1 blocker that is also a serotonin antagonist
Definition
Cyproheptadine
Term
Agents for reduction of postpartum bleeding
Definition
Oxytocin, ergonovine and ergotamine
Term

 Agents used in treatment of carcinoid tumor

Definition
Ketanserin, cyproheptadine, and phenoxybenzamine
Term
5HT-3 antagonist used in chemoterapeutic induced emesis
Definition
Ondansetron, granisetron, dolasetron, and alosetron
Term
5HT-3 antagonist that has been associated with QRS and QTc prolongation and should not be used in patients with heart disease
Definition
Dolasetron
Term
DOC of chemo induced N/V
Definition
Odansetron
Term
Drug used in ergot alkaloids overdose, ischemia and gangrene
Definition
Nitroprusside
Term
Reason ergot alkaloids are contraindicated in pregnancy
Definition
Uterine contractions
Term
SE of ergot alkaloids
Definition
Hallucinations resembling psychosis
Term
Ergot alkaloid used as an illicit drug
Definition
LSD
Term
Dopamine agonist used in hyperprolactinemia
Definition

Bromocriptine

(Cabergoline, pergolide)

Term
Peptide causing increased capillary permeability and edema
Definition
Bradykinin and histamine
Term
Mediator of tissue pain, edema, inactivated by ACE, and may be a contributing factor to the development of angioedema
Definition
Bradykinin
Term
5-HT-1a agonist that is an anxiolytic
Definition
Buspirone
Term
Metabolite of Serotonin
Definition
5-HIAA
Term
Ergot alkaloid used for migraines
Definition

Ergotamine

(partial alpha agonist)

Term
Ergot alkaloid that stimulates uterine SMC contraction; used for postpartum hemorrhage
Definition
Ergonovine
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