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Absite Killer Wound healing and cytokines
self explanatory
19
Medical
Professional
01/19/2014

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Cards

Term
Cells responsible for healing by secondary intention
Definition
myofibroblasts
Term
way in which myfibroblasts contract a wound
Definition
From the center
Term
Most abundant type of collagen
Definition
Type I
Term
Type of collagen in cartilage
Definition
type XI and II
Term
Type of collagen in bone and tendons
Definition
Type I
Term
Substrates required for hydroxylation of prolene
Definition
Vit C, Alpha-ketogluterate, oxygen and iron
Term
frequency of proline in normal collagen
Definition
every 3 AAs
Term
Order of arrival of cell types in a wound
Definition
Platelets, PMNs, macs, fibroblasts (dominant by day 5), lymphocytes
Term
Factor that stimulates fibroblasts
Definition
TGF-B
Term
Effects of TGF-B in wound healing
Definition
stimulates fibroblasts and chemtactic agent for PMNs
Term
Effects of PDGF in wound healing
Definition
chemotactic agent for fibroblasts; sitmulates matrix deposition
Term
Source of TNF in healing wound
Definition
Macrophages/monocytes
Term
Most potent stimulant for TNF production
Definition
Endotoxin/LPSa
Term
Effects of IL-1 on wound healing
Definition
Potentiates TNF
Increases IL-6
Increases endothelium adherence via selectins, ICAM and VCAM
Term
Source of IL-1 in wound healing
Definition
Macrophages/monocytes
Term
Responsible for wasting and cachexia
Definition
TNF
Term
Effects of TNF on wound healing
Definition
recruits and activates PMNs which leads to more cytokine production
Term
Cytokine responsible for fever
Definition
IL-1
Term
Milieu of acute phase response
Definition
Increase: CRP, amyloid, fibrinogen, haptoglobin, ceruloplasmin, and Alpha-1 antitrypsin
Decrease: albumin, transferrin and fibronectin
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