Term
Genome
- Kb's in e.coli v mammals |
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Definition
| The amount of DNA in one complete set of chromosomes. E. Coli has 4,200 kb; mammals have 3,000,000 kb |
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Term
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Definition
| Enzymes that catalyze the polymerization of DNA. They are also involved in DNA repair. there are five DNA polymerases in bacteria, with two main ones dedicated to replication; I and III. There are a number of mammalian polymerases. |
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Term
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Definition
| The main enzyme responsible for chain elongation during DNA replication. It consists of 2 complexes, each containing 10 subunits. Each 10-subunit complex is responsible for synthesizing 1 of the two daughter DNA strands at the replication fork. |
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Term
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Definition
| Site at which DNA replication is initiated |
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Term
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Definition
| Y-shaped forefront region of DNA replication, moving sequentially from the origin of replication |
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Term
| Unidirectional/Bidirectional replication |
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Definition
| One or two replications set out from the origin, most replication is bidirectional |
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Term
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Definition
| Newly synthesized strand formed by 5' to 3' polymerization in the direction of replication fork movement; DNA synthesis is continuous for this strand. |
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Definition
| Newly synthesized strand formed 5' to 3' polymerization in the direction OPPOSITE the movement of the replication fork. DNA synthesis in this strand is discontinuous. |
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Definition
| RNA primers that are DNA extended by DNA polymerase as part of discontinuous lagging DNA synthesis |
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Definition
| Enzyme that synthesizes RNA primers for DNA replication |
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Term
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Definition
| Unwinds DNA double helices at the front of the replication fork at the expense of ATP |
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Term
| Single-strand DNA binding proteins (Helix destabilizing proteins) |
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Definition
| Bind to and stabilize unwound exposed DNA strands |
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Term
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Definition
| Minor site of replication and transcription with own genome and ribosome |
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