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4) Chapter 29
pharmacology fscj 2011
38
Nursing
Undergraduate 3
10/26/2011

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Term
Bacteriostatic effect
Definition
inhibits bacteria growth
Term
batericalcidal effect
Definition
kills bacteria
Term
define nocosomial
Definition
hospital aquired infection
Term
define superinfection
Definition
(occurrence of a secondary infection when the flora of the body is disturbed
Term
Common adverse reactions to penicillin administration are
Definition
hypersensitivity and superinfection
Term
evere allergic reaction to penicillin
Definition
anaphylactic shock
Term
mild to moderate allergic reaction to penicillin
Definition
rash
Term
pseudomembranous colitis
Definition
infection of the large intestine (colon) with an overgrowth of Clostridium difficile bacteria.
Term
2 antibacterial drugs
Definition
tetracycline and sulfonamides
Term
2 bacteriostatic drugs
Definition
penicillins and cephalosporins)
Term
Penicillinase, an enzyme produced by the microorganism, is responsible for causing its_______
Definition
penicillin resistance
Term
The additive effect is
Definition
is equal to the sum of the effects of two antibiotics.
Term
The potentiative effect
Definition
occurs when one antibiotic potentiates the effect of the second antibiotic, increasing their effectiveness.
Term
. The antagonistic result of multi antibiotic combinations..`
Definition
The antagonistic result is a combination of a drug that is bactericidal, such as penicillin, and a drug that is bacteriostatic, such as tetracycline. When these two drugs are used together, the desired effect may be greatly reduced.
Term
Three major adverse reactions associated with the administration of antibacterial drugs are
Definition
allergic (hypersensitivity) reactions, superinfection, and organ toxicity
Term
what do beta-lactam antibiotics do?
Definition
These antibiotics work by inhibiting bacterial cell wall synthesis, causing the bacteria to lyse and die.
Term
Beta-Lactamase Inhibitors
Definition
break down the bata-lactamase based protective barrier around the microbes.
Term
Beta-Lactamase Inhibitors are often combined with a
Definition
broad-spectrum antibioti
Term
The first-generation cephalosporins are _______ by beta-lactamases
Definition
destroyed
Term
Third-generation cephalosporins are _____ to beta-lactamases
Definition
resistant
Term
cephalosporins all have what common part in their drug names?
Definition
Cepha/cefa
ex) cephalexin, cefadroxil
Term
The side effects to cephalosporins include
Definition
GI disturbances (nausea, vomiting, diarrhea), alteration in blood clotting time (increased bleeding)
Term
The side effects to cephalosporins include
Definition
GI disturbances (nausea, vomiting, diarrhea)
Term
adverse reactions to cephalosporins include
Definition
alteration in blood clotting time (increased bleeding) with administration of large doses, and nephrotoxicity (toxicity to the kidney) in individuals with a preexisting renal disorder.
Term
first-generation cephalosporin example
Definition
cefazolin (Duricef)
Term
second-generation cephalosporin example
Definition
cefaclor (Ceclor, Raniclor)
Term
Third-Generation cephalosporin example
Definition
ceftriaxone (Rocephin)
Term
4th generation cephalosporin example
Definition
cefepime (Maxipime)
Term
labs for cephalosporin
Definition
blood urea nitrogen, serum creatinine
Term
Advise client to ingest _____or _____ to prevent superinfection of the intestinal flora with long-term use of a cephalosporin.
Definition
buttermilk or yogurt
Term
side effects from use of oral cephalosporin drugs; t
Definition
these may include anorexia, nausea, vomiting, headache, dizziness, itching, and rash.
Term
1. A client is receiving amoxicillin (Amoxil). The nurse knows that the action of this drug is by which process?

a. Inhibition of protein synthesis

b. Alteration of membrane permeability

c. Inhibition of bacterial cell-wall synthesis

d. Alteration of synthesis of bacterial ribonucleic acid
Definition
C
Term
2. Amoxicillin (Amoxil) is prescribed for a client who has a respiratory infection. The nurse is teaching the client about this medication and realizes that more teaching is needed when the client makes which statement?

a. “I should not take my medication with food.”

b. “I will take my entire prescription of medication.”

c. “I should report to the physician any genital itching.”

d. “I should report to the health care provider any excess bleeding.”
Definition
A
Term
3. A client is prescribed dicloxacillin (Dynapen). The nurse plans to monitor the client for which side effect/adverse reaction?

a. Seizures

b. Renal failure

c. Hypertension

d. Hemolytic anemia
Definition
D
Term
4. A client is taking cefoperazone (Cefobid). The nurse anticipates which appropriate nursing intervention(s) for this medication? (Select all that apply.)

a. Monitoring renal function studies

b. Monitoring liver function studies

c. Infusing IV medication over 30 minutes

d. Monitoring client for mouth ulcers

e. Advising client to take medication with food
Definition
A B C D
Term
5. A client has been prescribed cefaclor (Ceclor). The nurse knows what fact about this medication?

a. It has a normal adult dose of 2 grams q6h.

b. It has a common side effect of hypotension.

c. It has an intramuscular administration route.

d. It is used to treat respiratory infections.
Definition
D
Term
6. Penicillin G (Pentids) has been prescribed for a client. Which nursing intervention(s) should the nurse include for this client? (Select all that apply.)

a. Collect C & S prior to first dose.

b. Monitor client for mouth ulcers.

c. Instruct client to limit fluid intake to 1000 mL/day.

d. Have epinephrine on hand for a potential severe allergic reaction.
Definition
A B D
Term
7. A client is prescribed cephradine (Velosef). The nurse should follow which nursing implication(s)? (Select all that apply.)

a. Report seizures to the health care provider.

b. Advise client to eat yogurt to prevent a superinfection.

c. Monitor client for an allergic reaction especially after first and second dose.

d. Advise client to take medication on an empty stomach even if GI distress occurs.

e. Culture infected area prior to first dose of medication.
Definition
A B C E
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