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305 exam4 lec.5
acute infl. response
17
Biology
Undergraduate 3
12/04/2013

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Term
acute inflammatory response attracts -- to -- microbes while -- accumulates
Definition
WBC
engulf
fluid
Term
1. Acute inflammatory response-
recognition by --; release --
Definition
Recognition by macrophages; release “help” cytokines
------------
macrophages
tend to hang out in tissues monitor for unusual activity and consume microbes and send out cytokines to tell other cells.
Term
2.Acute inflammatory response-
-- to host cells releases --
Definition
Damage to host cells releases bradykinin
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Bradykinin opens gaps in enothelial single layer of cells lining the blood vessel. The cells on the inside release a series of adhesion molecules that make neutrophiles (most prevelant WBC in blood) slow down and push themselves thru extravasation squeeze thru gaps in cells and release enzyme ending up in tissue where macrophage is. =fluid accumulation. Swelling= edema
Term
3. Acute inflammatory response-
cytokines --
Definition
Cytokines increase endothelial adhesion molecules (ICAM/VCAM)
Term
4. Acute inflammatory response-
Definition
Rolling WBC stick + stop, squeeze through gaps (extravasation/diapedesis) toward infection/injury
Term
5. Acute inflammatory response-
Definition
Fluid accumulates (edema=swelling)
Term
6. Acute inflammatory response-
Definition
Neutrophils phagocytize microbes, die quickly
Term
7. Acute inflammatory response-
Definition
Pus (cells and blood proteins) forms.
Term
Interferons are a -- response
Definition
innate
Term
fever is a -- response
Definition
innate
Term
Interferons are -- antiviral -- that help --. # of types
Definition
Non-specific Antiviral cytokines help prevent infection.
2 types
Term
type 1 interferons:
Definition
Inhibit viral RNA production/destroy viral RNA
Term
type 2 interferons:
Definition
Activates WBC
Term
Fever is caused by -- binding at --
Definition
Cytokines bind at hypothalamus regulator
Term
What is the benefit to a fever?
Definition
Temperature increases= mesophiles(most pathogens) don’t like above 37 degrees.
Term
slide 6 notes
Definition
Term
A virus that would be effected by type 1 interferons
Definition
influenze- the viral RNA would be destroyed
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