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2010 biotech drugs - MOA
drug and its mechanism of action
41
04/20/2010

Additional Pharmacology Flashcards

 

Cards

Term
Trade name/generic
 Definition
mechanism of action
Term
Advexin
 Definition
express p53 in tumor cells
Term
Amevive/alefacept
 Definition
antagonist of CD2 receptor
Term
Atacicept
 Definition
block antibody secretion
Term
Avastin
 Definition
block tumor vascularization
Term
Bexxar/tositumomab
 Definition
irradiate malignant B cells
Term
Campath/alemtuzumab
 Definition
destroy lymphoma cells
Term
Cimzia/certolizumab
 Definition
suppress autoimmunity
Term
Erbitux/cetuximab
 Definition
block EGF stimulation of tumor growth
Term
Farletuzumab
 Definition
block tumor folate uptake
Term
Herceptin/trastuzumab
 Definition
suppress HER2 positive tumors
Term
Humira/adalimumab
 Definition
suppress autoimmunity
Term
Ilaris/canakinumab
 Definition
suppress excess IL-1beta
Term
Lucentis/ranibizumab
 Definition
block retinal blood vessel growth
Term
Macugen
 Definition
block retinal blood vessel growth
Term
Mipomersen
 Definition
suppress LDL synthesis
Term
Mylotarg/gemtuzumab ozogamicin
 Definition
deliver toxin to AML cells
Term
Ontak/denileukin diftitox
 Definition
deliver toxin to malignant T cells
Term
Orthoclone/muromonab
 Definition
suppress T cells
Term
Prolia/denosumab
 Definition
inhibit osteoclast activity
Term
Remicade/infliximab
 Definition
block TNF-alpha
Term
ReoPro
 Definition
block platelet adhesion
Term
Rexin-G
 Definition
block cell cycle
Term
Rituxan/rituximab
 Definition
suppress malignant B cells
Term
Simponi/golimumab
 Definition
suppress autoimmunity
Term
Simulect/basiliximab
 Definition
block activated T cells
Term
Soliris/eculizumab
 Definition
prevent complement activation
Term
Stelara/ustekinumab
 Definition
blocks IL-12/23 activity
Term
Stimuvax
 Definition
stimulate anticancer immunity
Term
Symlin/pramlintide acetate
 Definition
amylin mimetic
Term
Synagis/palivizumab
 Definition
stimulate antiviral immunity
Term
Syncria/albiglutide
 Definition
agonist
Term
Tarceva/erlotinib
 Definition
inhibits HER1 kinase
Term
Tarvacin/bavituxumab
 Definition
stimulate antiviral immunity
Term
Trovax
 Definition
stimulate abticancer immunity
Term
Tysabri/natalizumab
 Definition
block leukocyte invasion
Term
Uplyso/taliglucerase alpha
 Definition
digest cerebrosides
Term
Vectibix/panitumumab
 Definition
block EGF stimulation of tumor growth
Term
Xolair/omalizumab
 Definition
lower IgE levels
Term
Zenapax/daclizumab
 Definition
block activated T cells
Term
Zevalin/Ibritumomab tiuxetan
 Definition
irradiate malignant B cells