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1st Generation Antipsychotics
1st Generation Antipsychotics
8
Pharmacology
Professional
08/23/2012

Additional Pharmacology Flashcards

 


 

Cards

Term
These agents are primarly what type of blockers?
Definition
Dopamine blockers - excess DA can cause psychosis.
Term
First Generation Antipsychotics are Dopamine Blockers.
Definition
Statement. Not a question.
Term
What is the black box warning for all first generation antipsychotics
Definition

increase mortality in elderly patients with dementia - related psychosis, primarily due to increased risk of stroke

Term
Describe, generally, EPS for 1st generation antipsychotics
Definition

all are sedating and all cause EPS, however the lower - potency agents have increased sedation and decreased incidence EPS (e.g. chlorpromazine), and the higher - potency agents have decreased sedation (but still sedating) with increased EPS (e.g. haloperidol).

Term
Name the 1st generation antipyschotics
Definition

Chlorpromazine

Thioridazine

Loxapine

Perphenazine

Fluphenazine

Haloperidol

Trifluoperazine

Thiothixene

 

Term
Describe the movement disorders that first generations can cause.
Definition

Tardive dyskinesia (TD): facial movements. Higher risk in elderly.

 

Dystonias: prolonged contraction of muscles (including painful muscle spasms). Higher risk with younger males.

 

Dyskinesias: abnormal movements

 

Akathesia: restlessness with anxiety and an inability to remain still.

Term
Cardiovascular Effects of first generation antipsychotics?
Definition
Orthostasis, tachycardia, Qt prolongation.
Term
What is the IM formulation of haloperidol used for?
Definition
Decanoate (monthly): IM only, for conversion from PO, use 10 - 20x the oral dose.
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